班佐提亚,班佐提亚及其衍生物在尿液中的度与肺癌之间的关联:一项嵌套病例对照研究
Weili Mao1, Jianli Qu2, Huimeng Liu3
1Department of Pharmacy, Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, Zhejiang, 324000, PR China.
Environmental research
|March 24, 2024
概括
尿液中暴露于西醇 (BTH) 和2-基西醇 (2-OH-BTH) 与患肺癌的风险更高有关. 这项研究强调了可能导致肺癌发展的环境因素.
科学领域:
- 环境健康 环境健康
- 职业医学 职业医学是专业的.
- 癌症流行病学 癌症流行病学
背景情况:
- 西 (BTH) 和西 (BTR) 衍生物是新兴的环境污染物.
- 之前的研究表明,BTHs和BTRs对呼吸系统有不良影响.
- 没有先前的研究研究过BTHs/BTRs暴露与肺癌风险之间的联系.
研究的目的:
- 检查尿液中BTH和BTR度与肺癌风险之间的关联.
- 为了研究这些协会在总体人口队列在中国的Quzhou.
- 为了确定肺癌的潜在环境风险因素.
主要方法:
- 在昆州环境暴露和人类健康 (QEEHH) 队列中进行了一个嵌套的病例控制研究.
- 涉及20694名参与者,在2019年4月至2020年7月期间收集了尿样.
- 212例肺癌病例与对照病例相匹配,并使用条件后勤回归来估计几率比率 (OR).
主要成果:
- 尿液BTH水平升高与肺癌风险增加显著相关 (OR=1.95在最高四分之一).
- 尿液中较高的2-基西醇 (2-OH-BTH) 水平也与患肺癌的风险增加有关 (OR=1.83).
- 在对共变量进行调整后,这些关联仍然显著,并且没有受到社会人口统计学因素的改变.
结论:
- 暴露于BTH和2-OH-BTH的高水平可能与肺癌的风险增加有关.
- 尿中的BTH和2-OH-BTH可以作为肺癌风险的生物标志物.
- 进一步的研究是有必要的,以了解机制和公共卫生的影响.
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