在接受结直肠手术的手术后增强康复的患者中,胺不耐受
Sarah B Stringfield1, Anthony C Waddimba2, Keirsyn M Criss3
1Department of Surgery, Baylor University Medical Center, Dallas, Texas, United States.
概括
在结直肠手术患者中观察到高胺不耐受率,双眼视是最常见的副作用. 尽管如此,胺显著降低了手术后的阿片类药物消费,但没有增加住院时间.
科学领域:
- 麻醉学 麻醉学
- 药理学 药理学是指药理学的学科.
- 结肠直肠手术 结肠直肠手术
背景情况:
- 胺提供抗过敏和抗耐受性作用,有利于手术后增强恢复 (ERAS) 协议.
- 诸如幻觉,镇静和双视等不良影响可能会限制胺的临床效用.
- 了解胺的副作用概况对于优化术后疼痛管理至关重要.
研究的目的:
- 为了确定在ERAS协议内接受结直肠手术的患者中胺的副作用的发生率.
- 为了比较短期的结果,包括疼痛得分和阿片类药物消费,在胺素接受者和对照者之间.
- 评估胺耐受性与不耐受性对术后结果的影响.
主要方法:
- 对接受ERAS结直肠手术的成年患者进行了回顾性观察队列研究.
- 患者被分为接受胺和前胺 (对照) 组.
- 使用倾向评分调整的模型分析了胺使用,耐受性和结果之间的关联.
主要成果:
- 29%的胺类药物接受者经历了不耐受,双眼眼是最常见的副作用.
- 两组之间没有发现住院时间的显著差异.
- 胺类药物的使用与术后阿片类药物的消费量较低有关,不论耐受程度如何.
结论:
- 胺素不耐受率高,需要在ERAS协议中仔细选择和监测患者.
- 胺有效地减少了结直肠手术后的阿片类药物消费,提供了一个有价值的非阿片类药物止痛药选择.
- 尽管有不耐受性,但胺在减少阿片类药物使用方面的好处超过了这种手术背景下的潜在缺点.
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