这不仅仅是鞭毛 - - 病原性螺旋虫的粘性入侵
Martin Strnad1, Nobuo Koizumi2, Shuichi Nakamura3
1Institute of Parasitology, Biology Centre CAS, Branišovská 31, 37005, České Budějovice, Czech Republic; Faculty of Science, University of South Bohemia, Branišovská 1760, 37005, České Budějovice, Czech Republic.
Trends in parasitology
|March 24, 2024
概括
病原性螺旋虫利用表面分子,而不仅仅是鞭毛,进行运动. 这些粘着分子及其宿主相互作用对于螺旋体的迁移和疾病传播至关重要.
科学领域:
- 微生物学 微生物学
- 病原体生物学 病原体生物学
- 细胞移动性 细胞移动性
背景情况:
- 病原性螺旋虫会导致人类的重大疾病,如莱姆病和梅毒.
- 由鞭毛体驱动的螺旋体运动性被认为是关键的毒性因素.
- 主流观点认为螺旋体是被动的弹性体,而鞭毛是唯一的运动驱动器.
研究的目的:
- 为了研究表面暴露的粘合分子在螺旋体运动中的作用.
- 挑战对螺旋体运动机制的传统理解.
- 要突出宿主-病原体相互作用对螺旋体迁移的贡献.
主要方法:
- 对螺旋体表面结构的分析.
- 对粘合分子与宿主分子相互作用的研究.
- 显微镜和生物力学测试观察螺旋体运动.
主要成果:
- 螺旋体表面暴露的粘合物分子对细胞运动有显著的贡献.
- 螺旋体粘附素和宿主分子之间的动态相互作用影响迁移.
- 螺旋体细胞体力学在运动中发挥着积极的作用,而不仅仅是被动弹性.
结论:
- 螺旋体运动是一种复杂的过程,涉及鞭毛和表面粘合物.
- 表面粘合素及其与宿主之间的相互作用对于螺旋体传播至关重要.
- 螺旋体细胞体是运动中的积极参与者,挑战了以前的模型.
相关概念视频
Intracellular Movement of Viruses and Bacteria
2.8K
Intracellular bacteria and viruses often comprise a group of highly infectious pathogens that can cause several diseases. Bacterial pathogens include those belonging to the genus Rickettsia responsible for conditions such as rocky mountain spotted fever and the Mediterranean spotted fever; Chlamydia, a genus responsible for a sexually transmitted disease; Coxiella burnetii, an agent responsible for Q fever. Viral pathogens include vaccinia—a poxvirus, and herpes simplex virus—a...
2.8K
Infection
7.9K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
7.9K
Defense Against Bacterial Pathogens
1.4K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.4K
Cytoskeletal Proteins in Bacteria
3.4K
Bacterial cells were initially considered simple, randomly organized structures lacking a cytoskeleton. However, the discovery of cytoskeleton homologs in bacteria led to the change of this opinion. Bacterial cytoskeletal filaments regulate the cell shape, cell polarity, cell division, and partitioning of plasmids during cell division. It was later discovered that bacterial cytoskeletal proteins, mainly actin and tubulin homologs, are diverse compared to their eukaryotic counterparts. On the...
3.4K
Adherens Junctions
4.8K
Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types – adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic
Adherens Junctions are Dynamic
4.8K
Lysogenic Cycle of Bacteriophages
62.1K
In contrast to the lytic cycle, phages infecting bacteria via the lysogenic cycle do not immediately kill their host cell. Instead, they combine their genome with the host genome, allowing the bacteria to replicate the phage DNA along with the bacterial genome. The incorporated copy of the phage genome is called the prophage. Some prophages can re-activate and enter the lytic cycle. This often occurs in response to a perturbation, such as DNA damage, but can also transpire in the absence of...
62.1K


