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Updated: Jun 29, 2025

Establishing Cell Lines Overexpressing DR3 to Assess the Apoptotic Response to Anti-mitotic Therapeutics
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在多发性骨髓瘤中,NT157通过准IRS和STAT3/5信号来表现出抗瘤作用

Gustavo Nery de Queiroz1, Keli Lima2, Livia Bassani Lins de Miranda1

  • 1Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.

Hematology, transfusion and cell therapy
|March 24, 2024
PubMed
概括

这项研究探讨了多发性骨髓瘤 (MM) 中的IGF1/IGF1R途径,发现一种新型抑制剂NT157有效地向MM细胞. NT157通过降低细胞活力和促进细胞亡,有望增强MM疗法.

关键词:
血液学的恶性瘤.在IGF1/IGF1R轴上多发性骨髓瘤是一种多发性骨髓瘤.美国国家安全委员会 NT157瘤抑制可以抑制瘤.

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