口腔和肠道微生物通过氧化还原通路进行通信吗? 这是一种酸盐-酸盐-NO通路的新兴资产
Beatriz Paiva1, João Laranjinha1,2, Bárbara S Rocha1,2
1Faculty of Pharmacy, University of Coimbra, Portugal.
FEBS letters
|March 24, 2024
概括
酸盐调节氧化 (NO) 的生物可用性,有利于口腔和肠道微生物群. 这项研究探讨了微生物群-宿主通过含有酸盐的氧化还原通路的通信如何连接这些关键的生态系统.
科学领域:
- 微生物学 微生物学
- 生理学 生理学 生理学
- 生物化学 生物化学
背景情况:
- 酸盐代谢通过酸盐-酸盐-NO通路影响健康.
- 微生物群与宿主之间的相互作用对于维持平衡至关重要.
- 氧化还原信号传递在细胞通信中起着关键作用.
研究的目的:
- 通过氧化还原通路阐明微生物群与宿主通信的分子机制.
- 调查酸盐在关联口腔和肠道微生物群中的作用.
- 了解NADPH氧化酶在宿主反应中的参与.
主要方法:
- 关于分子机制的讨论.
- 分析涉及氧化 (NO) 和氧化剂的氧化还原通路.
- 对NADPH氧化酶家族成员 (Duox2,Nox1,Nox2) 的检查.
主要成果:
- 酸盐调节NO的生物可用性,影响微生物群.
- NADPH氧化酶产生活性氧物种 (ROS) 和过氧酸盐.
- 微生物代谢物激活Nox2,通过Nrf2和NFkB通路影响宿主粘膜.
结论:
- 酸盐通过氧化还原信号通过口腔和肠道微生物群之间起到中心作用.
- 微生物群-宿主通信涉及NO和NADPH氧化酶介导的氧化还原通路.
- 了解这些途径为与微生物群相关的疾病提供了新的治疗视角.
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