在严重的COVID-19中持续的低纤维素解质与纤维素解质抑制剂活性升高相关
Erica Okazaki1,2, Bárbara Gomes Barion1,2, Tania Rubia Flores da Rocha2
1University of Sao Paulo Medical School, Sao Paulo, Brazil.
Journal of thrombosis and thrombolysis
|March 25, 2024
概括
在轻度和严重的病例中,COVID-19会导致暂时的高凝血. 严重的COVID-19患者经历了持续的低纤维素分解,可能与长期的COVID有关.
科学领域:
- 医学研究 医学研究
- 血液学 血液学 血液学
- 传染性疾病 传染性疾病
背景情况:
- COVID-19与高凝血性和减少纤维素分解有关.
- 在COVID-19中,这些凝血变化的确切时间尚未完全理解.
研究的目的:
- 调查轻度和重度COVID-19中的凝血和纤维素分解的时间动态.
- 通过ROTEM测定,在症状出现后的前30天内评估这些变化.
主要方法:
- 研究了85名COVID-19患者 (轻度和重度) 和20名对照组的队列.
- 血液样本使用ROTEM测定在症状出现后30天内五次间隔进行分析.
- 测量了纤维素素,等离子素,PAI-1和α2-抗等离子素水平.
主要成果:
- 轻度的COVID-19从第二周开始表现出高凝血性,到第三周恢复.
- 严重的COVID-19从早期开始就表现出高凝血能力,到第4周就消失了.
- 严重的病例表现出持续的低纤维素溶解与升高的PAI-1和α2-抗等离子素.
结论:
- 在第一个月内,COVID-19会诱导轻度和重度的过渡性高凝血.
- 严重的COVID-19的特点是持续的低纤维素分解,可能导致长期COVID.
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