电力衰竭应该被视为健康衰老的生物标志物
Sandro R Freitas1, Carlos Cruz-Montecinos2,3, Sébastien Ratel4
1Laboratório de Função Neuromuscular, Faculdade de Motricidade Humana, Universidade de Lisboa, Cruz-Quebrada, Portugal. sfreitas@fmh.ulisboa.pt.
Sports medicine - open
|March 25, 2024
概括
我们建议"powerpenia",一个新的术语用于骨肌肉的功率损失,作为健康衰老的关键生物标志物. 这一概念,与萨尔科佩尼亚和迪纳佩尼亚一起,解决了整个寿命的功能衰退.
科学领域:
- 老年学是一门学科.
- 人体生理学 人体生理学
- 衰老的生物标志物
背景情况:
- 萨尔科佩尼亚 (骨肌损失) 和迪纳佩尼亚 (最大力量损失) 是与衰老相关的公认概念.
- 动力衰竭的重点是力量丧失,往往忽视了骨肌肉力量的关键作用.
- 现有研究表明,骨肌肉的力量对于健康的衰老是非常重要的.
研究的目的:
- 引入和定义"功率"作为骨肌肉功率下降的特定生物标志物.
- 为了突出研究的差距,没有专门解决肌肉力量在dynapenia的背景下.
- 建议强度衰减作为第三个关键生物标志物,除了肉衰减和活力衰减外,用于评估健康的衰老.
主要方法:
- 在2008年至2023年期间发表的关于肉类和动态的研究的文献综述.
- 分析在研究分类肌肉力量的具体测量分析.
- 为拟议的术语"powerpenia"开发概念框架.
主要成果:
- 在2008年至2023年期间,很少有研究 (共220项研究中的2项) 直接测量肌肉力量以进行肌痛症分类.
- 骨肌肉力量在以前关于健康衰老的研究中表现出更大的相关性.
- 在具体测量和概念化肌肉功率损失方面存在很大的差距.
结论:
- 应该正式承认"功率",定义为骨肌肉功率的丧失.
- 这个新术语专门针对功能衰退的一个关键方面,这种关键方面尚未完全被sarcopenia或dynapenia所涵盖.
- 电力衰竭,与缩症和动力衰竭一起,被认为是监测健康衰老和功能独立性的重要生物标志物.
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