在渐进性超核麻中缺食症的流行:系统性审查和元分析
Julia Glinzer1,2, Éadaoin Flynn1,3, Eleni Tampoukari1
1Department of Clinical Speech and Language Studies, Trinity College Dublin, University of Dublin, Dublin 2, Ireland.
Dysphagia
|March 25, 2024
概括
缺食症影响了78-89%的渐进性上核性麻 (PSP) 患者,而吸收影响了23.5%. 这些吞问题很常见,随着PSP的进展,这些问题可能会恶化.
科学领域:
- 神经学 神经学
- 吞障碍 吞障碍 吞障碍
- 流行病学 流行病学
背景情况:
- 渐进性超核性 (PSP) 是一种罕见的神经退行性疾病.
- 吞困难 (消化不良) 和渴望是PSP的已知并发症.
- 了解这些问题的普遍性对于患者的护理和管理至关重要.
研究的目的:
- 系统地审查和确定患有PSP的个体中食障碍和渴望的患病率.
- 通过元分析,综合现有关于PSP中吞和吸收的研究.
主要方法:
- 从创立到2022年4月,对六个电子数据库进行了系统搜索.
- 包含的研究报告了PSP患者的消化不良和渴望的患病率.
- 确认缺食症需要仪器评估,临床评估,查或患者报告的结果.
- 用随机效应的元分析来计算聚合的流行率.
主要成果:
- 综述中包括了12项研究,涉及877个初始记录.
- 食障碍的综合流行率在78%至89%之间,根据评估方法而有所不同.
- 吸血的综合流行率为23.5%.
- 包括的研究质量中等,并确定了偏差风险.
结论:
- 在中度严重的PSP患者中,缺食症非常普遍.
- 吸血影响了大约四分之一的人口,预计随着疾病的进展而增加.
- 未来的研究应该集中在使用仪器评估的PSP亚型的消化障碍的纵向发展上.
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