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癌症特异性风险预测与血清microRNA签名

Janhavi R Raut1,2, Megha Bhardwaj1, Ben Schöttker1,3

  • 1Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Cancer science
|March 25, 2024
PubMed
概括

一种新的血清微RNA风险评分 (miR-score) 准确预测结直肠癌. 这一得分还显示了与乳腺癌和肺癌风险的反向关联,这表明循环miRNA生物标志物在癌症风险评估中具有更广泛的实用性.

关键词:
乳腺癌 乳腺癌 乳腺癌在循环中的miRNA.结肠直肠癌是什么意思肺癌是一种肺癌.前列腺癌是前列腺癌.风险预测风险预测风险分层的分层化

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MicroRNAs01:22

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
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