用于治疗口腔角膜炎的粘粘剂输送系统:系统性审查和元分析
Carolina Yoshi Campos Sugio1,2, Amanda Aparecida Maia Neves Garcia1, Klaryssa Akemi de Araujo Kitamoto1,2
1Department of Prosthodontics and Periodontics, Bauru School of Dentistry, University of São Paulo (USP), Bauru, Brazil.
Oral diseases
|March 25, 2024
概括
粘膜粘合剂的临床和真菌学效果与口腔候群病常规治疗方法相比较. 这些药物输送系统提供了较低的应用频率和剂量,提供了一个有前途的替代疗法.
科学领域:
- 药理学和制药科学 药理学和制药科学
- 口腔医学和病理学
- 菌类学 菌类学是指菌类学.
背景情况:
- 口腔角膜炎是一种常见的真菌感染,需要有效的治疗策略.
- 常规抗真菌治疗口腔候群病的治疗方法在坚持和剂量方面可能有局限性.
- 粘膜粘合剂药物输送系统为改善治疗结果和患者遵守提供了潜力.
研究的目的:
- 系统地审查和分析粘膜粘合剂在治疗口腔角膜病的临床和真菌学有效性.
- 为了比较粘膜粘合剂与传统局部或全身抗真菌剂的疗效.
- 评估粘膜粘合剂在应用频率和剂量方面的潜在优势.
主要方法:
- 在多个数据库 (Medline/PubMed,SCOPUS,EMBASE,Web of Science,Cochrane Library,SciELO) 进行了全面的文献搜索,截至2023年8月.
- 涉及1869名参与者的11项研究符合系统性审查和元分析的纳入标准.
- 进行了研究质量,偏差风险和证据分级,随后进行了数据的统计元分析.
主要成果:
- 粘膜粘合剂配方,主要是含有米可纳的片剂,显示出与标准抗真菌治疗相比的临床和真菌学疗效.
- 在临床结果 (RR=0.907) 或真菌学清除 (RR=0.95) 方面,在粘膜粘合剂治疗和常规疗法之间没有观察到统计学上显著的差异.
- 在包括的研究中,总体偏差风险被评估为低.
结论:
- 粘膜粘合剂是治疗口腔角膜炎的可行替代品,其疗效与现有治疗方法相美.
- 粘膜粘合剂的一个显著优势是,它们可以将应用频率降低多达五倍,每日剂量降低多达20倍.
- 对粘膜粘合系统的进一步研究可以优化口腔角膜炎的治疗方案.
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