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在继续或在选择性切换到vedolizumab后,在患有炎症性肠病的患者中进行活衰减疫苗接种
Hisashi Shiga1, Hiroshi Nagai1, Yusuke Shimoyama1
1Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan.
患有炎症性肠病 (IBD) 的患者在切换到vedolizumab (VDZ) 治疗后可以安全地接受活衰减疫苗. 这种方法允许安全接种疫苗,并保持未免疫个体的疾病控制.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 维多利祖马布 (VDZ) 是一种适用于炎症性肠病 (IBD) 的肠选择性疗法,具有有利的安全性.
- 在接受免疫抑制治疗的患者中,活减弱疫苗通常是禁忌的.
- 评估活体减弱疫苗的安全性和可行性,在IBD患者切换到或继续VDZ至关重要.
研究的目的:
- 评估活体减弱疫苗在接受vedolizumab (VDZ) 的IBD患者中的安全性和免疫性.
- 在接种疫苗之前确定选择性切换到VDZ的可行性.
- 评估疫苗接种后的疾病活动维持和疫苗引起的感染.
主要方法:
- 在未免疫IBD患者中测量了麻疹,红疹,疹和水的抗体标位.
- 患者在继续VDZ期间或切换到VDZ后接受了活体减弱疫苗.
- 监测了疾病的严重程度,抗体反应和疫苗诱导感染的发生率.
主要成果:
- 37名未免疫IBD患者在VDZ治疗中接受了活衰减疫苗 (17名继续,20名切换).
- 疫苗接种后36/37名患者的疾病严重程度保持不变;90%的患者在54周继续使用VDZ.
- 在91.9%的患者中,抗体标位变得阳性或模两可,没有观察到疫苗引起的感染.
结论:
- 活体减弱疫苗可以安全地给予接受vedolizumab (VDZ) 免疫治疗的IBD患者.
- 选择性切换到VDZ之后接种疫苗是未免疫IBD患者的安全选择.
- 该战略支持改善IBD患者的疫苗覆盖率,而不会影响疾病控制.
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