男孩中部早期青春期:长期趋势和临床特征
Heta Huttunen1, Juho Kärkinen1, Tero Varimo1
1New Children's Hospital, Pediatric Research Center, Helsinki University Hospital, Helsinki 00014, Finland.
European journal of endocrinology
|March 25, 2024
概括
男性中部早熟青春期 (CPP) 的发病率正在增加,主要是由异常病例推动的. 有机CPP与年龄更小,身材更矮,丸激素水平更高有关,有助于诊断.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 生殖健康 生殖健康
- 临床研究 临床研究
背景情况:
- 人们越来越担心男孩早些时候开始青春期.
- 男人中部早熟青春期 (CPP) 的发病率增加.
- 需要区分有机CPP (OCPP) 和异常性CPP (ICPP).
研究的目的:
- 为了调查男性CPP的发病率.
- 为了确定OCPP的临床和耳学指标.
- 分析CPP和OCPP发病率的趋势.
主要方法:
- 基于登记册的回顾性研究.
- 分析了43名患有CPP的男孩的医疗记录 (1985-2014).
- 包括临床,耳学和内分泌数据.
主要成果:
- 在男孩中 (2010-2014) 的CPP发病率为每10,000人中0.34.
- 在1990年至2014年期间,男性CPP的总体发病率显著增加 (IRR 1.10).
- 由ICPP驱动的发病率增加;OCPP发病率保持稳定.
- 与ICPP患者相比,OCPP患者更年轻,更矮,并且基底的水平更高.
- 结合临床线索显示高精度 (AUC 0.84-0.97) 在区分OCPP从ICPP.
结论:
- 男性CPP发病率为1万分之0.34,其中26%具有内病理.
- CPP利率的上升主要是由于ICPP的增加.
- 年龄较小,身材较矮,丸激素水平较高是OCPP的关键指标.
- 利用多个临床线索可以帮助诊断CPP病因的诊断决策.
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