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恶性前列腺前后组织B细胞淋巴细胞表达变化的模式与前列腺癌进展有关

Sudha M Sadasivan¹, Ian M Loveless¹, Yalei Chen¹

¹Department of Public Health Sciences, Henry Ford Hospital, Henry Ford Health + Michigan State University Health Sciences, Detroit, Michigan, USA.

Cancer medicine

|March 25, 2024

概括

在前列腺癌发育期间T细胞和B细胞水平的变化可以预测疾病的进展. 在瘤附近的良性前列腺组织中增加的CD20+细胞与复发风险较低相关,而其他模式表明癌症更具侵略性.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
病理学病理学病理学

背景情况:

涉及T和B细胞的炎症在前列腺癌中很常见.
在致癌过程中淋巴细胞水平的动态变化及其对疾病进展的影响仍然不清楚.

研究的目的:

研究前列腺癌发育期间T细胞 (CD3+,CD4+) 和B细胞 (CD20+) 水平在空间和纵向上如何变化.
确定这些变化是否会影响生化复发的风险.

主要方法:

对73例前列腺癌病例的回顾性分析,包括诊断前和诊断后的组织样本.
使用免疫组织化学量化CD3+,CD4+和CD20+淋巴细胞的量化.
使用TADPole.对良性活检腺体 (BBG),瘤邻近的良性腺体 (TAG) 和恶性瘤腺体 (MTG) 的表达趋势进行集群.
考克斯的比例危险模型来评估淋巴细胞计数/趋势与生化复发时间之间的关联.

主要成果:

在TAG区域增加的CD20+细胞计数与显著降低生物化学复发风险相关 (HR=0.81,p=0.01).
低BBG和高TAG与MTG的CD20+表达模式预测了复发风险增加3.06倍 (p=0.03).
与TAG/MTG相比,某些显示BBG水平较低的CD3+表达模式与复发风险增加有关 (HRs3.03-4.82),尽管在统计学上并不显著.

结论:

CD3+和CD20+淋巴细胞的纵向和空间表达模式为前列腺癌进展提供了洞察力.
在致癌过程中,良性前列腺中的CD20+表达增加与更具侵略性的疾病过程有关.

关键词:

CD20 CD20 是一个CD20 CD20 是一个CD20.CD3 CD3 CD3 CD3 CD3 CD3 CD3 CD3 CD3 CD3 CD3 CD3 CD3 CD3 CD3 CD3 CD3 CD3 CD3 CD3 CD3 CD3 CD3 CD3 CD3 CD3 CD3 CD3 CD3 CD3 CD3 CD3 CD3 CD3 CD3 CD3 CD3 CD3 CD3 CD3 CD3 CD3 CD3 CD3 CD3 CD3 CD3 CD3 CD3 CD3 CD3 CD3 CD3 CD3 CD3 CD3 CD3 CD3 CD3 CD3 CD3 CD3 CD3 CD3 CD3 CD3 CD3 CD4 CD4 CD4 CD4 CD4 CD4 CD5 CD5 CD5 CD5 CD5 CD5 CD6 CD7 CD7 CD7 CD7 CD7 CD7 CD7 CD7 CD7 CD7 CD7 CD7 CD7 CD7 CD7 CD7 CD7 CD7 CD7 CD7 CD7 CD7 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 CD4 良性活组织活检生物化学复发的发生.这是一种炎症炎症炎症炎症.

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