认知衰退和脑血流异常的纵向轨迹在80多岁的男性中,具有正常的全球认知能力
Arkadiusz Siennicki-Lantz1, Lena André-Petersson2, Sölve Elmståhl1
1Section of Geriatric Medicine, Department of Clinical Sciences in Malmö, Lund University, Malmö, SWEDEN.
Cerebral circulation - cognition and behavior
|March 25, 2024
概括
几乎一半的非痴呆症八十多岁男性在视觉空间能力和记忆方面经历了认知衰退,这与前额和身区域脑血流 (rCBF) 减少有关.
科学领域:
- 神经科学是一个神经科学.
- 老年学是指老年学的学科.
- 医疗成像医学成像
背景情况:
- 在老年男性中,认知和 perfusion 变化被注意到,MMSE 分数>24.
- 之前的研究观察到老年男性的认知和脑血流 (rCBF) 发生变化.
研究的目的:
- 调查6882.82岁的非痴呆症男性认知领域的纵向变化.
- 为了将认知变化与区域大脑血流 (rCBF) 缺陷相关联.
主要方法:
- 103名非痴呆症男性 (MMSE>24) 在68岁和81岁时使用认知测试电池进行了评估.
- 在82岁时使用99mTc-HMPAO SPECT估计了区域大脑血流 (rCBF).
主要成果:
- 在68至82岁之间观察到显著的认知衰退,特别是在块设计 (SRB-3) 和本顿视觉保留测试中.
- 一个子组 (46%) 显示了视觉空间能力和记忆的最大下降,与认知测试预测因子相关.
- 与认知稳定的人相比,这个子组在额头,头顶和皮下区域表现出较低的rCBF.
结论:
- 大约一半的社区居民,非痴呆症的80岁男性MMSE>24体验视觉空间能力和情节性记忆的下降.
- 这些认知变化与前皮下皮层区域广泛的rCBF减少有关.
相关概念视频
Cognitive Development During Adulthood
96
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
96
Alzheimer's Disease: Overview
469
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
469


