在越南,2020年至2022年的里芬素耐药的Mycobacterium结核病,2020-2022年
Hung Van Nguyen1,2, Hoa Binh Nguyen1, Doan Thu Ha1
1National Lung Hospital, Hanoi, Viet Nam.
概括
越南的多药耐药结核病 (MDR-TB) 主要对一线药物表现出耐药性. 艾滋病毒感染是MDR-TB患者先前结核病发作的关键风险因素.
科学领域:
- 医学微生物学 医学微生物学
- 传染性疾病 传染性疾病
- 基因组学就是基因组学.
背景情况:
- 结核病仍然是一个全球卫生挑战,多药耐药结核病 (MDR-TB) 构成重大威胁.
- 越南面临着大量的结核病负担,需要对抗性菌株进行详细的流行病学和遗传学表征.
研究的目的:
- 分析越南河内和胡志明市MDR-TB的耐药性模式.
- 在MDR-TB患者中确定与先前的结核病发作相关的风险因素.
- 评估全基因组测序对预测耐药性的有用性.
主要方法:
- 来自河内和胡志明市的MDR-TB患者的描述性分析 (2020-2022年).
- 全基因组测序Mycobacterium结核病分离物以确定耐药性突变.
- 基因组预测与表型药物敏感性测试的比较.
- 多变量后勤回归用于确定先前结核病的风险因素.
主要成果:
- 来自233个分离物的全基因组测序数据显示,主要是2系菌株.
- 高灵敏度 (>90%) 预测一线药物耐药性,除了pyrazinamide (85%).
- 艾滋病毒感染被确定为先前结核病发作的主要危险因素 (OR5.1,p=0.021).
结论:
- 越南这些城市的MDR-TB在很大程度上对一线药物具有抗药性.
- 同时感染艾滋病毒是复发性结核病的重要危险因素.
- 全基因组测序是快速预测MDR-TB药物耐药性的宝贵工具.
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