在恒温,炎症和癌症中调节,维护和重塑高内皮静脉
1Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06520-8034.
Current opinion in physiology
|March 25, 2024
概括
高内皮静脉 (HEVs) 促进免疫细胞进入淋巴体结构. 它们在炎症和瘤中的适应性为向药物输送和免疫疗法增强提供了潜在的潜力.
科学领域:
- 免疫学 免疫学 免疫学
- 血管生物学 血管生物学
- 癌症生物学 癌症生物学
背景情况:
- 高内皮静脉 (HEVs) 是专门的血管,对于免疫细胞进入淋巴体器官至关重要.
- 在不同的淋巴细胞结构中,HEV在粘附分子表达 (例如,PNAd,MAdCAM-1) 中表现异质.
- HEVs的基因表达是可塑的,在发育,炎症和瘤中受到调节.
研究的目的:
- 探索高内皮膜静脉 (HEV) 的异质性和调节机制.
- 研究HEVs在瘤内的三级淋巴体结构中的作用及其对免疫治疗的反应.
- 确定HEV在治疗应用中的潜力,包括药物输送.
主要方法:
- 转录组分析以评估HEV基因表达模式.
- 在初级,二级和三级淋巴体结构中检查HEV特征.
- 瘤中HEV存在与临床结果和免疫治疗反应的相关性.
主要成果:
- 在不同的条件和器官中观察到HEV基因表达的显著异质性和可塑性.
- 瘤三级淋巴体结构内的HEV与有利的临床结果和免疫治疗反应有关.
- 发现免疫疗法诱导HEVs,促进免疫细胞进入并支持前体细胞.
结论:
- HEV的发展和调节是灵活的,特别是在炎症情况下.
- 与瘤相关的HEV作为治疗反应的生物标志物,可以在治疗上诱导.
- 向HEV调控为向各种病理部位 (包括瘤和自身免疫性病变) 输送药物提供了一个有希望的策略.
关键词:
癌症 癌症 癌症 癌症高端内皮静脉的静脉.免疫检查点封锁免疫检查点封锁炎症 炎症是一种炎症.淋巴结的 淋巴结的 淋巴结的粘膜地址因细胞粘附分子 (MAdCAM-1)边缘节点地址 (PNAd) 在线三级淋巴体器官的第三级淋巴体器官三级淋巴体结构的第三级淋巴体结构.文字转录学 (Transcriptomics) 是一个学科.瘤是一个瘤.更多相关视频
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