慢性淋巴细胞白血病脆弱性骨折的危险因素
Lloyd Petty1, Deborah Stephens2, Anu Sharma3
1Endocrinology, Diabetes, and Metabolism, University of Utah School of Medicine, Salt Lake City, USA.
Cureus
|March 25, 2024
概括
慢性淋巴细胞白血病 (CLL) 患者经常经历脆弱性骨折 (FFs),特别是在脊椎. 风险因素包括男性性别,糖尿病,吸烟,晚期Rai阶段,T分数超过-2.5,突出了针对性查和治疗的必要性.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 骨的新陈代谢 骨的新陈代谢
背景情况:
- 在慢性淋巴细胞白血病 (CLL) 患者中,异常的骨健康和脆弱性骨折 (FF) 很普遍.
- 确定CLL中FF的风险因素对于主动管理至关重要.
研究的目的:
- 研究诊断为慢性淋巴细胞白血病 (CLL) 的患者的脆弱性骨折相关的风险因素.
主要方法:
- 使用国际疾病分类 (ICD) 代码进行了一项队列研究,用于2000-2020年CLL患者的异常骨健康和FFs.
- 分析了89名CLL患者的数据,比较了那些有 (pFF) 和没有 (nFF) 之前的FF.
主要成果:
- 66%的CLL患者至少有一次FF,脊椎是最常见的部位 (81%).
- 对FF的风险因素包括男性性别 (RR 8.1),糖尿病 (RR 1.4),吸烟 (RR 1.3),Rai阶段>0 (RR 1.4),T分数>-2.5 (RR 1.8).这些风险因素包括男性性别 (RR 8.1),糖尿病 (RR 1.4),吸烟 (RR 1.3),Rai阶段>0 (RR 1.4),T分数>-2.5 (RR 1.8).
- 骨质疏松症 (T评分<-2.5) 在没有FF的患者中更常见 (71%的nFF与38%的pFF相比,P=0.02).
结论:
- 脊椎脆弱性骨折在CLL患者中很常见,即使T分数不表明骨质疏松症,也经常发生.
- 需要提高临床意识,并在CLL患者中针对脊椎FF进行查/治疗.
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