缓解细胞衰老和增强认知功能:神经认知障碍中视觉艺术介导的认知激活疗法
Manuela Campisi1, Luana Cannella1, Dilek Celik1
1Occupational Medicine, Department of Cardio-Thoraco-Vascular Sciences and Public Health, University of Padua, Padua, Italy.
Frontiers in aging neuroscience
|March 25, 2024
概括
视觉艺术介导的认知激活疗法 (CAT) 可以通过延长白细胞端粒长度 (LTL) 来减缓细胞衰老,特别是在男性中. 这种非药理学方法也改善了神经认知障碍患者的认知和功能能力.
科学领域:
- 老年学是一门学科.
- 神经科学是一个神经科学.
- 生物遗传学 生物遗传学
背景情况:
- 人口老龄化正在增加痴呆症的患病率,这给全球经济带来了重大挑战.
- 痴呆症护理正在越来越多地整合非药物干预措施.
- 生物衰老标志物和认知功能是神经认知障碍的关键指标.
研究的目的:
- 调查视觉艺术介导的认知激活疗法 (CAT) 作为痴呆症的非药物干预.
- 评估CAT对生物衰老标志物的影响:白细胞端粒长度 (LTL) 和DNA甲基化年龄 (DNAmAge).
- 评估CAT对神经认知障碍患者的认知和功能状态的影响.
主要方法:
- 一项纵向研究涉及20名患有轻度至中度神经认知障碍的患者.
- 在CAT干预之前和之后对认知和功能评估的分析.
- 在干预前和后测量生物衰老标志物 (LTL和DNAmAge).
主要成果:
- 在CAT干预后,白细胞端粒长度 (LTL) 显著延长 (p=0.0269),特别是在男性中 (p=0.0142).
- LTL延长与治疗持续时间 (p=0.0518),年轻年龄 (p=0.0357) 和高等教育 (p=0.0008) 有积极的相关性.
- 在各种领域 (p<0.0001) 观察到显著的认知和功能改善,而DNAmAge保持稳定.
结论:
- 视觉艺术介导的CAT通过延长LTL有效地缓解细胞衰老,特别是在男性中.
- 在痴呆症护理中,CAT显示出提高认知和功能状态的潜力.
- 像CAT这样的非药物干预措施为改善老龄人口福祉提供了有希望的途径.
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