在接受不孕评估的非阻塞性阿佐精子症患者中,生化性阴性腺症的患病率和临床影响
Arnold P P Achermann1,2, Sandro C Esteves1,2,3
1ANDROFERT, Andrology and Human Reproduction Clinic, Campinas, São Paulo, Brazil.
F&S reports
|March 25, 2024
概括
在非阻塞性精子缺血症 (NOA) 的不孕男性中,生化性阴性腺缺血很常见,影响80.8%. 这种情况影响精子检索的成功,并与丸体积,年龄和激素水平有关.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 安德罗学与人类学
- 不孕症研究 不孕症研究
背景情况:
- 非阻塞性精症 (NOA) 影响了相当一部分不育的男性.
- 生物化学性阴性过敏症,以低水平为特征,是患有NOA的男性潜在的并发症.
- 了解NOA中阴性过敏症的患病率和影响对于有效的不孕症管理至关重要.
研究的目的:
- 为了确定在被诊断为NOA的不孕男性中生化性阴性恋的患病率.
- 在这个人群中调查与低阴性恋相关的临床因素.
- 为了评估低阴性恋对精子采集 (SR) 成功率的影响.
主要方法:
- 进行了一项队列研究,涉及767名患有NOA的不育男性.
- 根据卵泡刺激激素和丸激素水平,患者被分为四组:高激素性低激素,正常激素性低激素,高激素性优激素和正常激素性优激素.
- 用多变量逻辑回归分析来评估阴性恋,临床因素和SR成功之间的关联.
主要成果:
- 生物化学性阴性恋的总体患病率为80.8%.
- 阴性双胞胎症与丸体积减少,雌激素水平降低和父亲年龄较大有关.
- 患有高原性双胞胎症的患者与正常性双胞胎患者相比,SR成功率较低.
结论:
- 在NOA的男性中,生物化学性性阴性性恋非常普遍.
- 双胞胎缺血症与特定的临床和组织病理因素有关,并对精子采集结果产生负面影响.
- 这些发现强调了评估和管理NOA男性的阴性腺体缺陷的重要性,以提高生育治疗的成功率.
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