炎症性和血管性蛋白质生物标志物之间的关联,以及与功能有关的心血管事件和死亡率
Barbara Salzinger1, Kristina Lundwall2, Marie Evans3
1Division of Nephrology, Department of Clinical Sciences, Danderyd Hospital, Karolinska Institute, Stockholm, Sweden.
Clinical kidney journal
|March 25, 2024
概括
纤维细胞生长因子23 (FGF-23) 是急性冠状动脉综合征 (ACS) 患者的独立预后标志物. 无论慢性病 (CKD) 状况如何,FGF-23水平都能预测主要的不良心血管事件和死亡.
科学领域:
- 心血管医学 心血管医学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 蛋白质组学是指蛋白质组学.
背景情况:
- 慢性病 (CKD) 和心血管疾病 (CVD) 负担之间的关系尚未完全理解.
- 在急性冠状动脉综合征 (ACS) 患者中调查炎症和血管原生生物标志物至关重要.
- 了解CKD如何影响这些关联是关键.
研究的目的:
- 在ACS患者中探索生物标志物,功能和结果之间的关联.
- 确定CKD状态是否会改变生物标志物与主要不良心血管事件加死亡 (MACE+) 之间的联系.
主要方法:
- 对1293名ACS患者进行了长期观察.
- 使用蛋白质组学方法分析了13种预先识别的生物标志物.
- 考克斯回归模型评估了与MACE+和CKD相互作用的生物标志物关联.
主要成果:
- 9个生物标志物显示与功能有相反的关联.
- 内皮细胞特异性分子-1 (ESM-1),FGF-23和跨膜免疫球蛋白-1 (TIM-1) 与MACE+有关.
- 只有FGF-23仍然与MACE+独立相关;没有生物标志物与CKD相互作用.
结论:
- 13个生物标志物中的9个随着功能下降而增加.
- 在ACS患者中,FGF-23独立预测了MACE+,不论是CKD.
- 对于有或没有CKD的ACS患者来说,FGF-23是显著的预后标志物.
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