在急症监护室治疗败血症的幸存者中表征心脏功能:试点研究协议
Kevin Garrity1,2, Christie Docherty1,3, Kenneth Mangion4
1Academic Unit of Anaesthesia, Critical Care and Peri-Operative Medicine, University of Glasgow, Glasgow.
CHEST critical care
|March 25, 2024
概括
败血症幸存者可能会出现心脏功能障碍和身体障碍. 在CONDUCT-ICU研究中,研究了这种联系,评估心脏功能和炎症,以了解重症监护后综合征 (PICS).
科学领域:
- 心脏病学 心脏病学
- 密集护理医学 密集护理医学
- 免疫学 免疫学 免疫学
背景情况:
- 败血症是常见的ICU入院原因,也是导致死亡的主要原因.
- 幸存者经常面临长期的身体,心理和认知障碍 (重症监护后综合征 - PICS).
- 败血症与心血管风险有关,这表明幸存者可能患有未确定的心脏病,影响功能恢复.
研究的目的:
- 为了确定ICU败血症幸存者的心肌功能障碍的患病率.
- 在PICS中探索心肌功能障碍和身体障碍之间的关联.
- 为有关败血症,心血管事件和功能缺陷的更大研究提供数据.
主要方法:
- 在苏格兰西部进行前性多中心试点研究 (CONDUCT-ICU).
- 在ICU出院时招募败血症幸存者,在出院后进行6-10周的随访.
- 测量心脏生物标志物 (热波宁,NT-proBNP),炎症标志物 (CRP,ILs,TNF-α) 和心血管磁共振成像.
主要成果:
- 将收集心脏功能,心肌损伤和败血症幸存者的全身炎症数据.
- 将探索心脏功能指数,生物标志物和患者报告的结果之间的关联.
- 将为未来的研究生成可行性和操作数据.
结论:
- 该研究将描述心脏功能障碍的患病率及其与败血症幸存者的功能障碍的联系.
- 这些发现将为未来研究PICS的机制和败血症对心血管的影响提供信息.
- 这项研究对于理解和减轻败血症幸存者的长期健康后果至关重要.
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