慢性肝炎E病毒表现为心脏移植患者中超氨基酶的升高
Islam Mohamed1, Kimberly Sanders2, Donald J Hillebrand3
1Department of Internal Medicine, University of Missouri-Kansas City, Kansas City, MO.
ACG case reports journal
|March 25, 2024
概括
肝炎E病毒 (HEV) 感染可能导致慢性肝炎,特别是在移植患者中. 利巴维林治疗导致心脏移植接受者的持续病毒学反应和肝酶正常化.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 病毒学 病毒学
- 移植医学 移植医学 移植医学
背景情况:
- 肝炎E病毒 (HEV) 是全球病毒性肝炎的重要原因.
- HEV基因型3和4越来越多地与慢性肝炎有关,特别是在免疫功能低下的个体和移植接受者中.
- 移植率的上升和免疫抑制有助于HEV感染的增加.
研究的目的:
- 在心脏移植患者中报告慢性肝炎E病毒感染病例.
- 描述HEV慢性肝炎在免疫受损宿主中的临床表现和管理.
- 突出利巴维林治疗在这个特定患者群体中的治疗结果.
主要方法:
- 一个75岁的心脏移植患者的病例报告.
- 根据临床症状和实验室发现,诊断慢性肝炎E病毒感染.
- 用利巴维林治疗和对病毒学反应和肝酶水平的监测.
主要成果:
- 患者出现了暗示慢性肝炎的非特异性症状.
- 诊断并确认了E型肝炎病毒感染.
- 尽管患有利巴维林诱导的血液溶解性贫血,但该患者实现了持续的病毒学反应.
- 在治疗后观察到肝酶的正常化.
结论:
- 慢性肝炎E病毒感染是心脏移植接受者的潜在并发症.
- 利巴维林可以成为HEV慢性肝炎的有效治疗选择,在免疫功能低下的患者中.
- 在利巴维林治疗期间,仔细监测副作用,如溶血性贫血,至关重要.
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