在稳定状态下高血型乙氨基细胞计数与COPD中空气道微生物群明确的形状无关
Jeanne-Marie Perotin1,2, Anaëlle Muggeo3, Quentin Lecomte-Thenot3
1Université de Reims Champagne-Ardenne, INSERM UMR-S 1250, P3Cell, Reims, France.
概括
稳定的慢性肺炎患者的高血红蛋白细胞计数 (BEC) 与频繁的恶化和症状相关,但与明显的呼吸道微生物群概况无关. 这一发现有助于理解COPD异质性.
科学领域:
- 肺部医学 肺部医学
- 微生物学 微生物学
- 临床免疫学临床免疫学
背景情况:
- 慢性阻塞性肺病 (COPD) 呈现出与呼吸道微生物群相关的临床异质性.
- 血红蛋白细胞计数 (BEC) 是COPD不良结果的生物标志物,包括恶化和FEV1下降.
研究的目的:
- 在稳定的COPD患者中,研究血中乙氨基酸细胞数 (BEC) 和呼吸道微生物群之间的关联.
- 为了确定COPD中BEC升高是否与特定的气道微生物组成有关.
主要方法:
- 稳定状态的成年COPD患者被分为低BEC (<300/mm3) 和高BEC (≥300/mm3) 组.
- 收集了液以进行扩展微生物培养,以确定可行的气道微生物群.
主要成果:
- 高BEC组 (32.2%) 报告说,与低BEC组 (67.8%) 相比,更频繁的恶化和明显的咳/吐.
- 在全球微生物群组成,细菌负载,α-多样性,占主导地位的族群或低BEC和高BEC组之间的性别分布方面没有观察到显著差异.
结论:
- 在稳定的COPD中,高BEC与以频繁恶化为特征的临床表型有关.
- 较高的BEC似乎与稳定的COPD中独特的可活性气道微生物群概况无关.
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