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基于碳的量子点和杂衍生物的合成和表征,以提高安德罗格拉化物在药物输送平台中的水友性
Nataniel Medina-Berríos1,2, Wenndy Pantoja-Romero1,2, Alexis Lavín Flores1,2
1Department of Chemistry, University of Puerto Rico, Rio Piedras Campus, San Juan 00925-253, Puerto Rico.
ACS omega
|March 25, 2024
概括
与碳基量子点 (CBQD) 结合水性药物,显著提高了它们的水溶性. 这一进步为开发有效的药物输送系统提供了一个有前途的战略,用于难以溶解的药物.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术纳米技术
- 制药科学 制药科学
背景情况:
- 疏水性药物在药物输送中存在重大挑战,原因是水溶性差.
- 基于碳的量子点 (CBQD),包括化 (S-CBQD) 和化 (N-CBQD) 变体,显示出作为药物载体的希望.
- 安德罗格拉福利德是一种众所周知的疏水药物,具有治疗潜力,但生物可用性有限.
研究的目的:
- 调查安德罗格拉福利德与CBQD,S-CBQD和N-CBQD的结合.
- 评估这种结合对药物的水友性和水相亲和性的影响.
- 评估这些纳米复合材料作为药物输送平台的潜力.
主要方法:
- 合成和表征CBQDs,S-CBQDs和N-CBQDs. 这些是CBQDs,S-CBQDs和N-CBQDs的合成和表征.
- 安德罗格拉福利德与合成的纳米材料的结合.
- 药物-纳米材料结合物的光学和结构性质的表征.
- 使用核磁共振 (NMR) 光谱法确定分区系数.
主要成果:
- 与CBQD,S-CBQD和N-CBQD的结合诱导了纳米材料光学和结构性质的明显变化.
- 安德罗格拉福利德的分配系数在结合后显著下降,从2.632降至0.1117,表明对水相的亲和力增加.
- 核磁共振分析证实了纳米复合材料的成功相互作用和形成.
结论:
- 将andrographolide与基于碳的量子点结合起来,有效地提高了其水友性.
- 这些纳米复合材料显示出开发用于疏水性药物的先进药物输送系统的巨大潜力.
- 该战略提供了一种可行的解决方案,以克服与难溶性治疗剂相关的生物可用性问题.
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