在COVID-19宿主严重程度和非生存中PADI2和PADI4多态的关联
Ilse Adriana Gutiérrez-Pérez1, Ivette Buendía-Roldán2, Oscar Zaragoza-García1
1Faculty of Chemical-Biological Sciences, Universidad Autónoma de Guerrero, Chilpancingo, Guerrero, 39000, Mexico.
Heliyon
|March 25, 2024
概括
PADI2和PADI4基因的遗传变异与COVID-19的严重程度和死亡有关. 特定的单核酸多态 (SNP) 和单核酸类型增加了COVID-19患者对严重疾病和死亡率的易感性.
科学领域:
- 遗传学 是一个遗传学.
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 丁丁氨酸减弱酶 (PAD) 酶与COVID-19的病原发生有关.
- 单核酸多态 (SNPs) 在PAD基因中对COVID-19严重性和死亡率的作用仍然未被调查.
研究的目的:
- 研究PADI2和PADI4基因中的特定SNP与COVID-19严重程度之间的关联.
- 评估这些遗传变异与患者死亡率和炎症生物标志物的相关性.
主要方法:
- 1045名COVID-19患者的基因定型用于PADI2 (rs1005753,rs2235926) 和PADI4 (rs11203366,rs11203367,rs874881) 的SNP,使用TaqMan测定.
- 对SNP,单元型,疾病严重程度 (PaO2/FiO2),死亡率和炎症标志物之间的关联进行分析.
主要成果:
- 在PADI2中的rs1005753 G/G基因型与对严重COVID-19的易感性有关.
- 特定的PADI4异合体基因型 (rs11203366,rs11203367,rs874881) 表示存在死亡风险.
- 在PADI2-PADI4中,GTACC,GCACC和GCGTG类型与COVID-19的严重程度,对死亡的保护和炎症标志物水平 (PLR,中性粒细胞到血红蛋白,淋巴细胞,公素,D-二极体,CRP,LCRP,NHL,SII,NLR) 有不同的关联.
结论:
- 在PADI2和PADI4基因中的哈普洛类型和基因型有助于COVID-19的严重程度和死亡率.
- 这些遗传因素可能会影响COVID-19患者的疾病进展和炎症反应.
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