运动神经元疾病患者的便秘:一个回顾性的纵向研究
Yuki Yamamoto1,2, Koji Fujita1, Hiroki Yamazaki1
1Department of Neurology, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-cho, Tokushima, Japan.
Heliyon
|March 25, 2024
概括
在运动神经元疾病 (MND) 中,便秘很常见,在18个月内影响超过一半的患者. 肠道营养使用是这些患者发展便秘的关键风险因素.
科学领域:
- 神经学 神经学
- 胃肠病学 胃肠病学
背景情况:
- 便秘是运动神经元疾病 (MND) 的新出现的并发症,与运动和自主功能障碍有关.
- 在MND患者中长期便秘的特征尚不清楚.
- 肌缩侧面硬化症 (ALS) 是MND的一个主要例子.
研究的目的:
- 纵向调查一组MND患者中便秘的患病率.
- 确定与MND患者便秘相关的危险因素.
主要方法:
- 来自单一中心注册的日本MND患者的回顾性分析 (2017年6月至2021年12月).
- 基于更新的阿瓦吉标准进行ALS诊断;包括其他MND亚型.
- 使用罗马III标准评估便秘;临床数据组间比较.
主要成果:
- 155名患者中有30.3%在诊断时患有便秘,在18个月后增加到52.9%.
- 便秘组表现出更高的女性性别,气管切除术,侵入性通风和肠道营养率.
- 较低的修订ALS功能评分表得分,特别是运动功能,在便秘组中被注意到.
- 肠道营养是便秘的一个独立风险因素 (OR 3.69,p=0.005).
结论:
- 便秘在MND患者中非常普遍,其中包括运动障碍患者.
- 对MND患者来说,有效的排便管理至关重要,特别是那些接受肠道营养的人.
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