代谢综合征是否会增加对比诱导的脏病在正常功能患者?
Hasan Shemirani1, Ali Hosseini2
1Cardiology Department, Isfahan Cardiovascular Research Center, Cardiovascular Research Institute and Chamran Cardiovascular and Medical Research Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
概括
代谢综合征在冠状动脉血管造影后显著增加了对比诱导性病 (CIN) 的风险. 与没有这种情况的患者相比,代谢综合征患者的CIN发病率更高.
科学领域:
- 心脏病学 心脏病学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 对比诱导性脏病 (CIN) 是冠状动脉动图 (CAG) 和穿皮冠状动脉干预后的一个显著并发症,与死亡率和发病率的增加有关.
- 代谢综合征 (Mets) 患者代表着越来越多的接受这些手术的人群,但他们对CIN的特定风险需要进一步阐明.
研究的目的:
- 为了比较CIN发生率在接受CAG的代谢综合征和没有代谢综合征的患者中.
- 评估代谢综合征与发展对比诱导脏病的风险之间的关联.
主要方法:
- 一项病例控制研究涉及260名接受CAG的患者,分为130名Mets和130名没有Mets的患者,所有患者的基线功能正常.
- 血清肌氨酸 (Cr) 水平在血管造影前和48小时和72小时后进行测量.
- 统计分析包括双向ANOVA与重复测量和后勤回归模型.
主要成果:
- 代谢综合征与较高的甘油三,禁食血糖和透静血压以及较低的HDL-C有关.
- 这两组在血管造影后都显示出血尿 (BUN) 和Cr水平的增加.
- 在注射后48小时和72小时增加的Cr水平的发生率在Mets组显著更高 (分别P=0.016和P=0.021).
- 发展代谢综合征与急性损伤 (AKI) 的风险增加显著相关,增加脏病风险 (OR=7.14,P=0.001).
结论:
- 代谢综合征是对比引起的脏病的重要独立风险因素.
- 与没有代谢综合征的患者相比,CIN的发生率在患有代谢综合征的患者中要高得多.
- 识别和管理代谢综合征对于在接受CAG的患者中减轻CIN风险至关重要.
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