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人工甜味饮料的消费和与肥胖有关的癌症的风险:一个广角的门德尔随机化研究

Xing Jin¹, Mengyue Wu², Shuangshuang Dong³

¹Department of Laboratory Medicine, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China.

Frontiers in nutrition

|March 25, 2024

概括

人工甜味饮料的消费可能会增加结肠直肠癌和乳腺癌的风险. 体重指数 (BMI) 可能调解ASB摄入量与结直肠癌风险之间的联系.

科学领域:

营养流行病学营养流行病学
遗传学是一个遗传学.
癌症研究癌症研究

背景情况:

人工甜味饮料 (ASB) 消费与与肥胖相关的癌症 (ORCs) 之间的关系正在争论中.
这项研究调查了ASB摄入量与ORC风险之间的潜在遗传联系.

研究的目的:

探索ASB消费与肥胖相关癌症风险之间的遗传因果关系,使用广角门德尔随机化 (MR).
为了确定ASB与癌症相关的潜在调解因素.

主要方法:

使用全基因组关联研究 (GWAS) 总结统计数据进行了单变量,多变量和两步MR分析.
采用各种统计方法,包括IVW,MR-Egger和因果推断的加权中位数.
进行了广泛的灵敏度分析,以确保针对混因子,异质性和性质的发现的稳定性.

主要成果:

基因预测的ASB消费与结直肠癌 (CRC) 风险 (OR:6.879) 和乳腺癌风险 (OR:3.881) 有积极关联.
多变量MR分析证实了这些关联.
两步MR表明,体重指数 (BMI) 在ASB消费和CRC风险之间的关系中显著调解.

结论:

ASB的消费与大多数ORC没有因果关系,但对于CRC和乳腺癌存在潜在的关联.
体重指数 (BMI) 可能在ASB消费与CRC风险之间的关联中起到调解作用.

关键词:

这就是为什么BMI是BMI.门德尔的随机化人工甜味饮料的人工甜味饮料癌症的风险癌症的风险肥胖肥胖肥胖肥胖肥胖肥胖肥胖肥胖糖糖糖糖糖糖糖糖

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