在老年人中,用低剂量氨基酸成分刺激肌肉蛋白质合成
David D Church1, Arny A Ferrando1, Robert R Wolfe1
1Department of Geriatrics, Donald W. Reynolds Institute on Aging, Center for Translational Research in Aging and Longevity, University of Arkansas for Medical Sciences, Little Rock, AR, United States.
Frontiers in nutrition
|March 25, 2024
概括
低剂量的必需氨基酸 (EAA) 加上氨酸有效地刺激老年人肌肉蛋白质的合成. 这一发现表明,基于EAA的肌肉健康干预措施的有效剂量较低.
科学领域:
- 营养科学 营养科学
- 肌肉生理学 肌肉生理学
- 老年学是一门学科.
背景情况:
- 基本氨基酸 (EAA) 对于刺激肌肉蛋白质合成至关重要.
- 对于EAA用于此目的的最低有效剂量,特别是在老年人中,仍然不清楚.
- 之前的研究表明,基于EAA的成分是有效的,但剂量反应数据有限.
研究的目的:
- 在老年人中,确定肌肉蛋白合成对特定低剂量的EAA加阿尔金因的反应.
- 量化EAA摄入后肌肉蛋白的分数合成速率 (FSR).
- 评估摄入EAA在低剂量刺激肌肉蛋白质合成方面的效率.
主要方法:
- 利用稳定同位素追踪器方法来测量肌肉蛋白质合成.
- 给老年人服用3.6g剂量的高素EAA成分加上阿尔金因.
- 在摄入后的3小时内测量肌肉蛋白分数合成速率 (FSR).
主要成果:
- 肌肉蛋白FSR在摄入EAA剂量后3小时内每小时增加0.058%.
- 观察到的FSR增加代表了摄入EAA相对于总肌肉质量的约80%的利用率.
- 通过低剂量的EAA,可以实现肌肉蛋白质合成的显著刺激.
结论:
- 低剂量的必需氨基酸,包括氨酸,可以有效地刺激老年人肌肉蛋白质的合成.
- 这些发现表明,低于先前假定的剂量可能足以促进肌肉蛋白质合成.
- 这项研究为优化老年人群肌肉健康的营养策略提供了宝贵的见解.
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