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Microbial Biosensors

Microbial Biosensors

Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...

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Updated: May 2, 2026

Using Extraordinary Optical Transmission to Quantify Cardiac Biomarkers in Human Serum

Using Extraordinary Optical Transmission to Quantify Cardiac Biomarkers in Human Serum

Published on: December 13, 2017

一个基于表面等离子体共振和弱值放大功能的超敏感生物传感器.

Lizhong Zhang¹, Mingyi He², Yang Xu¹

¹Institute of Optical Imaging and Sensing, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Shenzhen International Graduate School, Tsinghua University, Shenzhen, China.

Frontiers in chemistry

|March 25, 2024

概括

一种新的弱测量表面等离子体共振 (WMSPR) 生物传感器增强了IgG检测灵敏度. 这种基于相位的传感器实现了显著更高的折射率灵敏度和较低的检测极限,用于改进的生物传感应用.

关键词:

生物分子相互作用生物传感器生物传感器折射指数传感器的折射指数传感器表面的等离子体共振.弱值放大放大功率的使用.

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相关实验视频

Last Updated: May 2, 2026

Using Extraordinary Optical Transmission to Quantify Cardiac Biomarkers in Human Serum

Using Extraordinary Optical Transmission to Quantify Cardiac Biomarkers in Human Serum

Published on: December 13, 2017

Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor

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Published on: February 16, 2018

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科学领域:

塑制剂的使用方法
生物感应是一种生物感应.
光学计量学在光学计量学

背景情况:

表面等离子共振 (SPR) 是一种广泛使用的无标签生物传感技术.
提高SPR传感器的灵敏度和分辨率仍然是检测低度分析物的关键挑战.
基于阶段的检测方法比传统的基于强度的SPR提供了潜在的优势.

研究的目的:

为IgG检测提出并展示一种超敏感的相位等离子传感器.
利用弱值放大 (WVA) 来提高SPR系统的折射率灵敏度.
在灵敏度,分辨率和检测极限方面调查拟议的WMSPR生物传感器的性能.

主要方法:

开发一个基于金的镜合SPR结构的WMSPR生物传感器.
利用p-和s-极化光之间的自我干扰来进行相位检测.
采用相补偿器和WVA原理来调节合强度并放大相位移.

主要成果:

该WMSPR传感器实现了4.737 × 10^4 nm/RIU的高折射率灵敏度,大约是传统基于相位的SPR的三倍.
显示了6.333 × 10^-8 RIU的高分辨率.
实现了IgG检测的5.3 ng/mL的低检测极限 (LOD).

结论:

拟议的WMSPR生物传感器显著提高了生物分子检测的灵敏度和分辨率.
将WVA与基于阶段的SPR集成为开发下一代超灵敏生物传感器提供了一个有前途的战略.
这种方法对优化其他基于SPR的传感平台具有广泛的影响.