75岁以上和75岁以下的患者的血糖控制和痴呆风险
1Department of Medicine, Kangwon National University School of Medicine, Kangwondaehakgil, Chuncheon, Gangwon-Do 24341 South Korea.
Diabetology international
|March 25, 2024
概括
血糖控制显著影响老年人的痴呆风险. 较低的禁食血糖水平与老年糖尿病患者的痴呆和死亡风险较低有关,与年轻人相比,糖尿病控制不良的风险增加更大.
科学领域:
- 老年学是一门学科.
- 内分泌学 在内分泌学.
- 神经学 神经学
背景情况:
- 关于血糖控制对老年人新发性痴呆症的影响的数据有限.
- 糖尿病是老年人群中普遍存在的疾病,需要对其并发症进行研究.
研究的目的:
- 研究血糖控制与老年糖尿病患者明显痴呆的发生率之间的关联.
- 为了比较禁食血糖水平对不同年龄组痴呆风险的影响.
主要方法:
- 一项全国性的韩国队列研究分析了79,076名75岁及以上的糖尿病患者和74,672名50-74岁的糖尿病患者.
- 在治疗期间,禁食血糖 (FBG) 水平每年平均,在9年的随访期间估计痴呆发病率.
- 多变量分析检查了FBG水平和痴呆症/死亡风险之间的J形关联,考虑了年龄组的相互作用.
主要成果:
- 在两个年龄组中,在FBG水平上观察到J形关联对痴呆风险,年龄有显著的相互作用.
- 最低痴呆和死亡风险的最佳FBG范围在75岁及以上的患者中较低.
- 与年轻患者相比,老年人患痴呆症的绝对风险增加和由于控制不良的葡萄糖而导致的死亡率在老年人中更大.
结论:
- 降低痴呆和死亡风险的理想血糖目标在老年糖尿病患者中较低.
- 有效的血糖管理对于减轻痴呆风险至关重要,特别是在老年糖尿病人群中.
- 这项研究强调了糖尿病管理的年龄特定考虑,以防止认知能力下降.
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