心率变量 (HRV) 作为多发性硬化症中痛苦和症状负担的客观相关值
Giuseppina Pilloni1, Pamela Best1, Ilya Kister1
1Department of Neurology, New York University Grossman School of Medicine, 222 E 41st Street, 10th floor, New York, NY 10017, United States.
概括
自主神经系统 (ANS) 功能障碍,以较低的心率变化 (HRV) 表示,与多发性硬化症 (MS) 症状严重程度的增加有关. 情绪上的痛苦完全解释了这种联系,表明HRV是MS症状负担的潜在客观标志物.
科学领域:
- 神经学 神经学
- 心脏病学 心脏病学
- 心理学 心理学 心理学
背景情况:
- 自主神经系统 (ANS) 功能障碍在多发性硬化症 (MS) 中很常见.
- 心率变化率 (HRV) 客观地衡量ANS功能及其与慢性疾病症状负担的联系.
- 身体和心理因素影响ANS功能,促使人们对MS症状严重程度的痛苦和ANS功能障碍进行调查.
研究的目的:
- 研究MS患者的情绪困扰,ANS功能障碍和症状严重程度之间的关联.
- 为了确定通过HRV测量的ANS功能障碍是否与MS症状负担相关.
- 探索情绪困扰在ANS功能和MS症状严重程度之间的关系中扮演的调解角色.
主要方法:
- 招募多发性硬化患者和健康对照 (HC) 用胸监视器自行收集心率 (HR) 数据.
- 对收集的HR信号进行了短期HRV分析 (时间和频率域).
- 将MS和HC组之间的HRV值进行比较,并将其与自我报告的痛苦和MS症状严重程度相关联.
主要成果:
- 与HC相比,MS参与者表现出明显较低的副交感激活和整体HRV.
- 在MS患者中,较低的HRV (HF-HRV) 与自我报告的MS症状严重程度的增加有显著的相关性.
- 多发性硬化参与者报告了更高的痛苦水平,HRV与痛苦严重程度有负相关性,情绪上的痛苦完全调解了HRV-症状负担关系.
结论:
- 减少HRV,表明ANS功能障碍,可以作为MS症状负担的客观生物标志物.
- 在MS中,情绪困扰在ANS功能障碍和症状严重程度之间的关联中起着至关重要的调解作用.
- 针对情绪困扰可能是管理MS患者症状负担的潜在策略.
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