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申古颗粒可以通过肠-骨-免疫轴改善卵巢切除诱导的骨质疏松症
Xiao Cong Chen1,2, Wei Ju Li1,3, Jia Ying Zeng1,3
1Guangzhou University of Chinese Medicine, Guangzhou, China.
Frontiers in microbiology
|March 25, 2024
概括
申古颗粒通过恢复肠道菌群平衡和减少炎症来改善绝经后的骨质疏松症. 这种治疗增强了骨强度,并调节了肠-骨-免疫轴,提供了一种新的治疗方法.
科学领域:
- 综合医学和骨生物学.
- 肠道微生物组和宿主相互作用
- 免疫学和炎症的研究
背景情况:
- 绝经后骨质疏松症 (PMOP) 的特点是骨密度和力量的减少.
- 中国医学,特别是Shengu颗粒,在管理PMOP方面表现有前途.
- 肠道微生物群在PMOP中的作用和Shengu颗粒的机制仍然不清楚.
研究的目的:
- 调查Shengu颗粒是否通过调节肠道微生物群来减弱PMOP.
- 探索涉及肠道菌群,炎症和骨代谢的潜在机制.
- 评估Shengu颗粒对大腿骨强度和肠道健康的影响.
主要方法:
- 评估大腿骨强度,肠道微生物群结构和便短链脂肪酸 (SCFA).
- 对结肠FOXP3细胞,肠粘膜状况和血清细胞因子水平 (IL-10,TGF-β,IL-17,TNF-α) 的分析.
- 对OPG,RANKL (股骨),ZO-1和Occludin (结肠) 的蛋白质表达的评估.
主要成果:
- 与OVX组相比,Shengu颗粒显著改善了骨质疏松症,增加了肠道菌群的多样性,SCFA和FOXP3表达.
- 治疗减少了肠道炎症和改变了血清细胞因子配置,有利于抗炎性标记物 (IL-10,TGF-β).
- 申古颗粒对ZO-1,奥克卢丁和OPG进行了上调,同时对RANKL进行了下调,表明肠道屏障改善和骨重塑平衡.
结论:
- 申古颗粒有效地改善了PMOP中的肠道菌群失衡和SCFA分泌.
- 治疗可以减少炎症,修复肠道屏障,调节OPG/RANKL轴.
- 申古颗粒通过肠-骨-免疫轴改善卵巢切除诱导的骨质疏松症.
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