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乳牛患有由Streptococcus agalactiae引起的乳腺炎的细胞因子炎症反应

Mariola Bochniarz¹, Agata Hahaj-Siembida¹, Monika Krajewska-Wędzina^1,2

¹Sub-Department of Veterinary Microbiology, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, 20-033 Lublin, Poland.

Journal of veterinary research

|March 25, 2024

概括

牛乳炎是由Streptococcus agalactiae引起的,可显著提高牛奶中的互白素 (IL) - 1β,IL-8,IL-12β和瘤坏死因子α (TNF-α) 水平. 这些细胞因子的度在牛奶中高于血清中,这表明尿液中的快速局部免疫反应.

科学领域:

兽医免疫学兽医免疫学
牛病理学牛病理学
微生物病原体的产生

背景情况:

牛乳炎是奶牛养殖中一个重要的经济问题.
杆菌 (Streptococcus agalactiae) 是导致传染性乳腺炎的主要病原体.
了解免疫反应对于有效的乳腺炎管理至关重要.

研究的目的:

为了评估Streptococcus agalactiae诱导的乳腺炎的奶牛中关键细胞因子的度.
为了比较感染和健康奶牛的血清和牛奶中的细胞因子水平.
为了阐明牛乳腺内的局部免疫反应.

主要方法:

用ELISA量化细胞因子水平.
样本包括来自波兰的荷尔斯坦-弗里西亚牛的血清和牛奶.
这项研究涉及60头患病的牛和30头健康的牛.

主要成果:

与健康对照群相比,在乳母牛的牛奶中发现了显著更高的IL-1β,IL-8,IL-12β和TNF-α水平.
牛奶中的细胞因子度明显高于受感染牛的血清.
乳牛乳中的IL-1β,IL-8,IL-12β和TNF-α的特定平均度分别为263.03,298.34,604.10和460.86 pg/mL.

结论:

牛的免疫系统建立了一个强大的,局部防御S. agalactiae在里.
乳腺对S. agalactiae感染表现出快速而强烈的炎症反应.
这些发现强调了细胞因子在牛乳腺炎早期阶段的关键作用.

关键词:

链球菌的 agalactiaeae 是一个细菌.牛牛牛牛牛牛细胞因子细胞因子乳腺炎是一种乳腺炎.

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