神经发育障碍作为关节障碍的危险因素:来自孟德尔随机化研究的证据
Xueqiang Wu1, Zefang Li2, Yiping Cui2
1Department of Health Science, Shandong University of Traditional Chinese Medicine, Jinan, China.
Frontiers in genetics
|March 25, 2024
概括
注意缺陷/多动障碍 (ADHD) 显著增加患上关节障碍 (TMD) 的风险. 这项研究强调了ADHD和TMD之间的关键联系,建议进一步研究相关因素,如维生素D水平.
科学领域:
- 遗传学和精神病学 遗传学和精神病学
- 流行病学 流行病学
- 口腔和牙和面部医学
背景情况:
- 关节疾病 (TMD) 是一种影响关节和肌肉的疾病.
- 神经发育障碍 (NDD) 和TMD之间的关系需要进一步调查.
- 了解遗传倾向可以阐明疾病病因.
研究的目的:
- 为了确定患有精神疾病的个体中关节疾病的发病率.
- 调查注意力缺陷/多动症障碍 (ADHD),自闭症谱系障碍 (ASD),图雷特障碍 (TD) 和关节障碍 (TMD) 之间的潜在因果关系.
主要方法:
- 使用了两个样本的门德尔随机化 (MR) 设计.
- 从精神病基因组学联盟和FinnGen数据库中获取大规模遗传数据.
- 采用了反向变量加权 (IVW) 方法,使用灵敏度分析和对混因素的控制.
主要成果:
- 注意缺陷/多动性障碍 (ADHD) 与肌痛性肌痛症的风险增加有显著的关联 (OR = 1.2342,p < 0.00001).
- 此外,ADHD也显示出与TMD的显著关联,包括阿沃希尔莫 (OR = 1.1244,p = 0.00003),TMD相关的疼痛 (OR = 1.1590,p < 0.00001),以及与纤维肌痛相关的TMD肌肉疼痛 (OR = 1.1815,p < 0.00001).
- 在ASD或TD和TMD之间没有发现显著的因果关系.
结论:
- 这项研究确立了ADHD和各种TMD方面的风险增加之间的重要联系.
- 这些发现表明,在ADHD和TMD之间的相互作用中,诸如维生素D水平等因素可能起作用.
- 需要进一步的研究来探索ADHD,ASD,TD和TMD之间的复杂相互作用.
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