食纤维对健康成年人肠道微生物群组成,功能和肠-大脑模块的影响 - - 一项系统性审查协议
David Antoine Lachmansingh1,2,3, Benjamin Valderrama2,3, Thomaz Bastiaanssen2,3
1Department of Psychiatry and Neurobehavioural Science, University College Cork, Cork, County Cork, Ireland.
HRB open research
|March 25, 2024
概括
饮食纤维摄入量影响健康个体的肠道微生物群组成. 这篇评论分析了研究,以了解纤维如何影响肠道微生物及其神经活性代谢物,可能影响大脑健康.
科学领域:
- 微生物组研究的研究.
- 营养科学 营养科学
- 神经科学是一个神经科学.
背景情况:
- 肠道微生物群在健康和疾病中起着至关重要的作用,微生物代谢物是关键的功能输出.
- 肠道微生物组成的变化与精神健康障碍有关.
- 食纤维可以调节肠道微生物群,影响细菌酶和代谢物产生,包括神经化学物质.
研究的目的:
- 在健康个体中进行食纤维干预后对肠道微生物群组成变化的研究进行系统审查.
- 从选定的研究中提取和重新分析公开可用的微生物基因组数据集,使用一致的生物信息学管道.
- 为了识别由食纤维干预导致的改变的神经活性肠-大脑模块.
主要方法:
- 在PubMed/MEDLINE和EMBASE数据库中的系统文献搜索.
- 包括原始干预试验和在健康成年人中随机对照研究 (交叉和非交叉设计).
- 用标准化生物信息学管道重新分析提取的微生物基因组序列数据.
主要成果:
- 食纤维影响肠道微生物群的组成,特定的纤维促进或减少某些细菌种群.
- 审查将汇集和更新现有的关于纤维诱导的微生物变化的观察结果.
- 重新分析旨在预测神经活性肠-大脑模块的功能后果.
结论:
- 食纤维显著改变健康个体的肠道微生物群组成.
- 了解这些变化对于预测神经活性通路的功能影响至关重要.
- 这一系统性审查和重新分析将为通过食纤维调节肠-大脑轴提供最新的见解.
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