开发和评估西尔代纳菲尔/甘酸载荷纳米纤维作为潜在的新型口腔输送系统用于勃起功能障碍
Ali A Alamer1, Abdullah A Alshehri1, Alhassan H Aodah1
1Advanced Diagnostics and Therapeutics Institute, Health Sector, King Abdulaziz City for Science and Technology (KACST), Riyadh 11442, Saudi Arabia.
概括
这项研究开发了双载纳米纤维,结合了西尔德纳菲尔和甘利,用于勃起功能障碍 (ED) 治疗. 这些纳米纤维提供了安全有效的口腔输送系统,提高了药物的生物可用性和患者对ED管理的遵守性.
科学领域:
- * 制药科学 制药科学
- * 纳米技术的使用
- * 药物交付服务 * 药物交付服务
背景情况:
- *勃起功能障碍 (ED) 是一个重要的健康问题,需要有效的治疗.
- *西尔德纳菲尔是ED的常见治疗药物,可以改善阴茎的血液供应.
- *目前的ED治疗可能在生物可用性和患者遵守性方面存在局限性.
研究的目的:
- * 制定和评估用于口服的西尔代纳菲尔和甘油的双重载荷纳米纤维.
- * 评估这些纳米纤维作为改善ED治疗方法的潜力.
- * 调查新型配方的安全性和有效性.
主要方法:
- * 西尔德纳菲尔和甘油被装入聚烯 (PVP) 纳米纤维中.
- *分析了纳米纤维特性 (直径,表面形态).
- *确定了药物加载效率,封装效率和体外药物释放概况.
- * 在人体皮肤纤维细胞上进行了体外细胞活力测试.
主要成果:
- * 锡尔德纳菲尔/甘油纳米纤维具有均直径 (0.719±0.177μm),没有表面缺陷.
- * 对于西尔代纳菲尔和糖素,都实现了高的药物加载和封装效率.
- *在第一分钟内观察到两种药物的快速释放,随后在120分钟内完全释放.
- *该配方表现出了卓越的安全性,在测试度下具有高细胞活力,特别是组合药物比率.
结论:
- * 西尔德纳菲尔/甘油双载纳米纤维代表了对ED的有前途的口腔输送系统.
- *这种配方增强了药物的生物可用性,确保了快速吸收,并改善了患者的遵守.
- *这项研究证实了这种新方法在治疗勃起功能障碍方面的安全性和治疗潜力.
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