瘤中的囊性特征和它们日益增长的临床和病理意义
Maria Tretiakova1, Jung Woo Kwon2, Gladell P Paner2,3
1Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA.
Advances in anatomic pathology
|March 25, 2024
概括
大多数囊性脏瘤,包括透明细胞和非透明细胞类型,往往具有惰的过程. 囊性特征有助于对瘤的分类和预测结果.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 大多数囊性脏瘤 (Bosniak IIF-IV) 尽管存在潜在的恶性瘤 (细胞癌,RCC),但表现出惰的行为.
- 清细胞组织学在囊性瘤中很常见,包括囊性清细胞RCC和低恶性潜力的多局部囊性瘤 (MCNLMP).
- 从MCNLMP到囊性和固体透明细胞RCC存在生物频谱,其中MCNLMP是最惰的.
研究的目的:
- 审查囊性脏瘤,专注于清晰细胞和非清晰细胞形态.
- 要突出具有囊性特征的新型RCC亚型.
- 强调囊性特征在瘤的分类和预后中的作用.
主要方法:
- 关于囊性脏瘤的文献综述.
- 分析组织学亚型及其临床行为.
- 囊性特征与成像 (波斯尼亚分类) 和预后的相关性.
主要成果:
- 广泛囊性透明细胞RCC (>75%) 显示出优异的结果,类似于MCNLMP.
- 其他囊性清晰细胞瘤,如清晰细胞乳头脏瘤和MED15::TFE3 RCC,也具有惰的过程.
- 在非清晰细胞RCC中存在囊性特征,其中一些具有转移潜力 (例如,管囊性,FH缺乏的RCC).
- 管囊性RCC可以呈现较低的波斯尼亚语分类,与良性囊重叠.
结论:
- 囊性特征对于分类和预测瘤的行为至关重要.
- 区分囊性瘤的组织学标准需要重新评估.
- 了解囊性脏瘤有助于准确的病理诊断和报告.
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