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一个供应商中立的EPI序列用于超极化CMRI

Tyler Blazey¹, Ashley Shaw¹, Cornelius von Morze¹

¹Mallinckrodt Institute of Radiology, Washington University, St. Louis, Missouri, USA.

Magnetic resonance in medicine

|March 25, 2024

概括

我们开发了一种灵活的,供应商中立的回声平面成像 (EPI) 序列,用于超极化13C代谢成像. 这种开源工具能够准确地定位代谢产物,并且可以免费用于研究.

科学领域:

医疗成像医学成像
生物物理学的生物物理.
代谢成像 - 代谢成像

背景情况:

超极化13C (碳-13) 成像提供了代谢洞察力.
现有的回声平面成像 (EPI) 序列可以是特定于供应商的,限制了更广泛的应用.
需要灵活的,开源的成像序列.

研究的目的:

开发一种多功能,供应商中立的EPI序列,用于高极化13C代谢成像.
创建一个开源工具,用于先进的代谢研究.
为了提高超极化13C成像技术的可访问性.

主要方法:

使用Pulseq框架开发了一个开源的EPI序列.
嵌入了特定于代谢物的光谱空间射频激发和可定制的EPI读数.
测试了具有不同空间分辨率的序列灵活性和含有13C化合物和超极化[1-13C]pyruvate的多腔幻体.

主要成果:

成功地将自然丰富的13C化合物和超极化的[1-13C]pyruvate局部化到指定的幻象区.
检测到的[1-13C]乳酸盐特别是在促进酸盐转化为乳酸盐的腔内.
量化了在0.01s−1.1时的酸盐到乳酸盐的转化率 (kPL).

结论:

一个供应商中立的EPI序列用于超极化13C成像已经成功开发和验证.
序列和重建代码的开源性质促进了更广泛的采用和研究.
这项工作为推进代谢成像研究提供了宝贵的工具.

关键词:

Pulseq 的意思是脉冲.一个回声平面成像仪.超极化的13C.代谢成像 - - 代谢成像提供商中立的

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