维生素D水平与血糖和胆固醇水平之间的关系
Eman Elsheikh1,2, Abdulhakim Ibrahim Alabdullah3, Sarah Saleh Al-Harbi4
1Internal Medicine Department, College of Medicine, King Faisal University, Alahsa 31982, Saudi Arabia.
低维生素D水平在沙特成年人中很常见,并且与糖尿病的更高风险和较差的脂质样本有关. 解决维生素D缺乏症可能有助于管理代谢健康并降低疾病风险.
科学领域:
- 内分泌学 在内分泌学.
- 代谢健康 代谢健康
- 公共卫生 公共卫生
背景情况:
- 全球维生素D缺乏的患病率很高.
- 观察性研究表明,低维生素D与代谢综合征,糖尿病和脂质失调之间存在联系.
- 关于维生素D补充对代谢标记的影响的干预数据有限.
研究的目的:
- 调查沙特成年人血清25-基维生素D (25(OH) D水平和代谢标志物之间的关联.
- 根据维生素D状态对参与者进行分层:充足 (≥30 ng/mL),不足 (21-29 ng/mL) 和缺乏 (≤20 ng/mL).
主要方法:
- 对476名年龄在15-78岁之间的沙特患者进行了回顾性横截面研究.
- 临床记录的分析,包括血清25(OH) D水平,糖尿病状态 (禁食葡萄糖,HbA1c) 和脂质资料.
- 参与者的分层分为维生素D的充足,不足和缺乏群体.
主要成果:
- 维生素D缺乏组 (18.3%) 与足够 (10.1%) 组相比,观察到糖尿病患病率更高.
- 更糟糕的脂质特征,包括增加的总胆固醇 (≥240毫克/分升) 和LDL (≥160毫克/分升),与较低的25~OH) D水平有关.
- 维生素D缺乏不成比例地影响女性和45岁以上的个人.
结论:
- 维生素D缺乏在沙特阿拉伯普遍存在,并且与不良的代谢标志物有显著联系.
- 通过查和纠正来优化维生素D状态可能是管理糖尿病流行病的成本有效策略.
- 提高维生素D水平可能会降低该地区心血管疾病的风险.
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