相关实验视频

Updated: Jun 29, 2025

MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier MSC for Lung Cancer Screening

MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier MSC for Lung Cancer Screening

Published on: October 26, 2017

循环miRNAs作为叶的新型临床生物标志物

Lorenza Guarnieri¹, Nicola Amodio², Francesca Bosco¹

¹Section of Pharmacology, Science of Health Department, School of Medicine, University "Magna Graecia" of Catanzaro, 88100 Catanzaro, Italy.

|March 25, 2024

概括

叶 (TLE) 是常见的,并且很难治疗. 循环中的microRNAs (c-miRNAs) 作为生物标志物,有望改善TLE患者的治疗和治疗结果.

科学领域:

生物化学生物化学
遗传学是一个遗传学.
神经学神经学

背景情况:

叶 (TLE) 是最常见的耐火焦点.
对于生物标志物来分类TLE患者进行量身定制的治疗非常需要.
循环微RNA (c-miRNA) 是体液中发现的小型非编码RNA.

研究的目的:

探索c-miRNAs作为TLE的诊断和预后生物标志物的潜力.
在TLE患者中识别失调c-miRNAs的一致签名.

主要方法:

审查最近的研究调查c-miRNAs在TLE患者的血清,血和脑脊液.
分析方法,队列组成和跨研究的规范化策略.

主要成果:

尽管有方法差异,但在TLE中观察到一种失调c-miRNA表达的常见模式.
c-miRNAs表现出细胞外稳定性,可以通过非侵入性检测.
c-miRNAs对TLE的病理变化和治疗干预有反应.

结论:

循环中的microRNAs的保存签名为TLE生物标志物开发提供了一个有前途的途径.
c-miRNAs有可能改善TLE患者分层,治疗和治疗结果.
需要进一步标准化方法,以便在TLE中强有力的c-miRNA生物标志物的临床应用.

关键词:

抗药物 (ASM) 是一种抗药.生物标志物生物标志物循环中的微RNA (c-miRNA)药物耐药性 (DRE) 是一种疾病.时间叶 (TLE)

更多相关视频

Cerebrospinal Fluid MicroRNA Profiling Using Quantitative Real Time PCR

Cerebrospinal Fluid MicroRNA Profiling Using Quantitative Real Time PCR

Published on: January 22, 2014

Harnessing the Power of MicroRNA Cargoes in Small Extracellular Vesicles Released from Fresh-Frozen Human Brain Sections

Harnessing the Power of MicroRNA Cargoes in Small Extracellular Vesicles Released from Fresh-Frozen Human Brain Sections

Published on: November 8, 2024

相关概念视频

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...