肺部参与复发性呼吸道 papilomatosis:一个系统性审查
Illari Sechi1, Narcisa Muresu2, Biagio Di Lorenzo3
1Department of Medicine, Surgery and Pharmacy, University of Sassari, 07100 Sassari, Italy.
Infectious disease reports
|March 25, 2024
概括
复发性呼吸道乳头瘤 (RRP) 患者患肺部并发症的风险低至中等. 人类乳头瘤病毒 (HPV) 11型增加了这种风险,强调了需要采取预防措施的必要性.
科学领域:
- 医学科学 医学科学 医学科学
- 在瘤学瘤学.
- 病毒学 病毒学
背景情况:
- 复发性呼吸道乳头炎 (RRP) 是一种非恶性疾病,会在呼吸道中引起状生长.
- RRP影响儿童 (青少年发病,JORRP) 和成人 (成人发病,AORRP),主要是由人类乳头瘤病毒 (HPV) 感染引起的.
- 严重的并发症,包括肺部参与和恶性转变,可能会发生,但很少发生.
研究的目的:
- 在JORRP和AORRP患者中系统地审查严重并发症的患病率,如肺部参与和肺部瘤.
- 评估HPV基因型与RRP患者疾病严重程度的进展之间的关联.
- 遵守PRISMA声明的系统审查和元分析指南.
主要方法:
- 在PubMed和Scopus上使用与RRP和肺瘤相关的关键词进行了系统的文献搜索.
- 总共有378项研究最初被确定.
- 十一项研究符合系统性审查的纳入和排除标准.
主要成果:
- 在RRP患者中,肺部参与的综合流行率为8% (95% CI: 4-14%).
- 在肺部瘤患者中,肺部瘤的综合患病率为4% (95% CI: 1-7%).
- 在91%的RRP患者中检测到HPV-6和HPV-11;在肺部感染患者中,HPV-11存在于21% (95%CI:5-45%),表明风险增加.
结论:
- RRP患者面临低至中等风险的肺部参与和肺部瘤.
- 患有HPV-11的患者有严重肺部并发症的风险增加.
- 需要进一步的研究,以提高理解,并制定预防性策略,防止严重的RRP进展.
更多相关视频
相关概念视频
01:27Pneumothorax-II
142
Pneumothorax is a medical condition defined by the buildup of air in the pleural space between the lungs and the chest wall. This accumulation of air can lead to partial or complete lung collapse, resulting in a range of clinical manifestations. Understanding the clinical presentation and effective management strategies is crucial for healthcare professionals in providing timely and appropriate care to individuals with pneumothorax.
Clinical Manifestations:
Clinical Manifestations:
142
01:31Pulmonary Tuberculosis III
325
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
325
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
2.8K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
2.8K
01:28Pneumonia IV: Management
324
The treatment of pneumonia varies based on its severity and the causative pathogen. Here is a structured approach to managing pneumonia, integrating pharmaceutical and supportive care strategies.
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
324