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Updated: Jun 29, 2025

The Importance of Correct Protein Concentration for Kinetics and Affinity Determination in Structure-function Analysis
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The Importance of Correct Protein Concentration for Kinetics and Affinity Determination in Structure-function Analysis

Published on: March 17, 2010

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植物性毒素simplexxin与牛蛋白激酶C的结合:从分子动态学的见解

Yuchen Zhou1, Ras Baizureen Roseli1, Natasha L Hungerford1,2

  • 1School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, QLD 4072, Australia. e.krenske@uq.edu.au.

Organic & biomolecular chemistry
|March 25, 2024
PubMed
概括

辛普勒辛是一种来自Pimelea植物的毒素,强烈地与牛蛋白激酶C (PKC) 结合. 这种对Pimelea中毒至关重要的结合通过键和膜相互作用得到增强,为潜在的治疗提供了洞察力.

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Analyzing Dynamic Protein Complexes Assembled On and Released From Biolayer Interferometry Biosensor Using Mass Spectrometry and Electron Microscopy

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Detection of Toxin Translocation into the Host Cytosol by Surface Plasmon Resonance10:41

Detection of Toxin Translocation into the Host Cytosol by Surface Plasmon Resonance

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Protein-Drug Binding: Mechanism and Kinetics01:16

Protein-Drug Binding: Mechanism and Kinetics

Protein-drug binding refers to the interaction between drugs and proteins within the body. This binding process can occur intracellularly, involving drug interactions with enzymes or receptors within cells, or extracellularly, involving plasma proteins in the blood.
Various forces drive these interactions, including hydrogen bonds, hydrophobic interactions, ionic bonds, electrostatic interactions, and van der Waals forces. These bonds enable drugs to bind to specific sites on proteins,...
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