与甲adrine故意自我中毒相关的临床结果:一个回顾性毒素中心研究研究
Nina Dhaliwal1,2, Darren M Roberts1,3
1New South Wales Poisons Information Centre, Sydney Children's Hospitals Network, Westmead, Australia.
Clinical toxicology (Philadelphia, Pa.)
|March 25, 2024
概括
过量服用奥菲纳德林可以引起抗肌糖毒性,但在本研究中没有观察到严重的心脏毒性. 甲adrine的配方可能会影响毒性,持续释放产品可能会导致不那么严重的结果.
科学领域:
- 毒理学 毒理学 毒理学
- 临床药理学 临床药理学
背景情况:
- 过量服用奥菲纳德林可以导致严重的抗肌肉素毒性,呼吸衰竭,和心脏毒性.
- 甲非纳德林剂量与毒性之间的关系还没有得到很好的定义.
- 立即释放与持续释放配方对orphenadrine毒性的影响尚不清楚.
研究的目的:
- 为了确定ORPHENADRINE在向毒素中心呈现的患者中的临床毒性.
- 为了研究奥菲纳德林的剂量毒性关系.
- 探索奥芬阿德林配方对毒性结果的影响.
主要方法:
- 在新南威尔士州 (2016年1月至2022年4月) 的ORPHENADRINE自我中毒患者的回顾性病例系列.
- 从临床数据库中提取有关人口统计,暴露,治疗和结果的数据.
- 用于识别毒性预测剂量值的接收器操作特征曲线.
主要成果:
- 分析了46名具有临床结果的患者和41名具有剂量信息的患者.
- 甲氨酸的中位数剂量为770毫克,59%的即时释放药物,67%的辅助药物.
- 常见的症状包括昏昏欲睡,鼻高心率和混乱;没有观察到严重的心脏毒性或神经事件.
结论:
- 服用高达10克的欧芬阿德林剂量与抗肌糖毒性和镇静有关,但与严重心脏毒性无关.
- 配方可能会影响结果,持续释放产品可能与较低的毒性有关.
- 需要进一步的研究来澄清剂量和配方对奥芬亚德林毒性的影响.
更多相关视频
11:14Rapid High-throughput Species Identification of Botanical Material Using Direct Analysis in Real Time High Resolution Mass Spectrometry
Published on: October 2, 2016
11.6K
08:05A Prediction Error-driven Retrieval Procedure for Destabilizing and Rewriting Maladaptive Reward Memories in Hazardous Drinkers
Published on: January 5, 2018
9.8K
相关概念视频
01:26Anticholinesterase Agents: Poisoning and Treatment
851
Anticholinesterases, also known as cholinesterase inhibitors, work by blocking the breakdown of acetylcholine, leading to its accumulation in the synaptic cleft. This accumulation indirectly enhances both muscarinic and nicotinic actions. These agents are classified as reversible or irreversible based on their mechanism of action.
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...
851
01:14Prevention of Further Absorption of Poison
820
In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...
820
01:19Pharmacovigilance
830
Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
830
01:26Enhanced Elimination of Poison
505
Poison can be effectively removed from the gastrointestinal (GI) tract through various decontamination procedures.
Antidotes serve a crucial role in counteracting the effects of poison by inhibiting enzymes responsible for producing harmful drug metabolites. In some cases, these toxic metabolites can be neutralized by endogenous cosubstrates, which are maintained at specific concentrations to prevent interaction with cellular macromolecules and subsequent cell death.
Renal excretion is the...
Antidotes serve a crucial role in counteracting the effects of poison by inhibiting enzymes responsible for producing harmful drug metabolites. In some cases, these toxic metabolites can be neutralized by endogenous cosubstrates, which are maintained at specific concentrations to prevent interaction with cellular macromolecules and subsequent cell death.
Renal excretion is the...
505
01:27Effects of Chemicals: Overview
1.3K
Drugs, encompassing various chemical compounds from natural sources, lab synthesis, or genetic engineering, elicit different biological responses in living organisms. Some of these responses are desirable or therapeutic, while others are undesirable. The primary goal of administering a drug is to achieve a therapeutic effect, that is, to address a specific disease or health condition. Any concurrent effects outside of this therapeutic outcome are considered undesirable. These undesirable...
1.3K
01:26Toxic Reactions: Overview
971
When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
971