这项TOPOS研究是TOPOS的研究
Tim Sebastian1, Stefano Barco1,2, Davide Voci1
1Department of Angiology, University Hospital Zurich, Switzerland.
VASA. Zeitschrift fur Gefasskrankheiten
|March 25, 2024
概括
斜静脉支架可以安全地用 iliac 静脉压缩治疗血栓后综合征 (PTS),在 24 个月内保持高通透率并显著减少症状.
科学领域:
- 血管外科 血管外科
- 干预心脏病学 干预心脏病学
- 静脉血栓塞栓症是一种静脉血栓塞栓症.
背景情况:
- 带有下静脉压缩的血栓后综合征 (PTS) 显著影响患者的生活质量.
- 内血管治疗是管理PTS的关键治疗选择.
- 对于PTS特定静脉支架的长期安全性和有效性数据至关重要.
研究的目的:
- 评估斜静脉支架在PTS治疗中的长期安全性和有效性.
- 评估初级支架通透性和24个月后的临床结果.
- 分析对PTS严重程度得分和生活质量的影响.
主要方法:
- 未来的,单臂的,跨国TOPOS研究.
- 60名PTS患者接受了 sinus-Obliquus®支架,可选的远端延伸.
- 主要终点:24个月初级支架通透性;次要:维拉拉塔得分,rVCSS,VAS,CIVIQ-20,并发症.
主要成果:
- 24个月的初级通透率为80.7%.
- 在Villalta得分,rVCSS,疼痛VAS和CIVIQ-20 (p<.001) 中显著降低.
- 急性支架封闭率低 (9) 和症状性狭窄症 (4);没有严重的出血或 contralateral 血栓形成.
结论:
- 用斜体支架和延伸进行内血管治疗对于PTS是安全的.
- 在24个月后观察到的高通透率和实质性,持续的PTS严重性降低.
- 支持使用斜静脉支架来管理PTS中阴道静脉压缩.
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