试点研究评估唾液胆酸作为喉回流的诊断生物标志物
Amanda J Krause1, Madeline Greytak1, Marco Kessler2
1Department of Medicine, Division of Gastroenterology & Hepatology, University of California San Diego, San Diego, CA, USA.
概括
唾液胆酸在患有喉症状和客观胃食道逆流病 (GERD) 的患者中升高. 这些发现表明,唾液胆酸可能作为喉回流的诊断生物标志物.
科学领域:
- 胃肠病学 胃肠病学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 生物化学 生物化学
背景情况:
- 反流中的胆酸与食道和喉症状有关.
- 在逆流中量化胆汁酸是可行的.
研究的目的:
- 为了比较健康对照和有症状的患者的唾液胆酸度,有或没有客观胃食道逆流病 (GERD).
- 为了研究唾液胆酸在喉回流的诊断潜力.
主要方法:
- 前性研究比较了三个组:食道症状,喉症状和对照组.
- 有症状的患者接受了无线反流监测;GERD定义为酸暴露时间≥4%.
- 唾液样本用超高性能液态染色学双重质谱分析胆汁酸.
主要成果:
- 与对照组 (5.8 nM) 和没有症状的GERD (3.1 nM) 相比,喉症状+GERD组 (24.2 nM) 的唾液胆酸总量最高.
- 胆酸在喉症状+GERD组的45%中升高,而在其他组中为0% (P<0.01).
- 唾液胆酸在患有喉症状和客观GERD的患者中显著增加.
结论:
- 唾液胆酸在患有喉症状和客观GERD的患者中是可量化的和升高的.
- 唾液胆酸显示出诊断潜力,可以作为喉回流的生物标志物.
更多相关视频
相关概念视频
Serum Laboratory Studies, Stool Test, Breath Test
343
Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...
343
Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
116
Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
116


