系统性硬化症患者的主导和对立手的功能障碍
Salomé Fourmond1, Simon Parreau2, Stéphanie Dumonteil2
1Division of Dermatology, Dupuytren University Hospital, Limoges, France. salome.fourmond@chu-limoges.fr.
Clinical and experimental rheumatology
|March 25, 2024
概括
系统性硬化症 (SSc) 显著影响主导手比非主导手更大,导致更大的关节限制和皮肤硬化. 需要进一步的研究来证实SSc患者的这些发现.
科学领域:
- 类风湿病学 类风湿病学
- 皮肤病学 皮肤病学
- 手术手术手术手术手术
背景情况:
- 在全身性硬化症 (SSc) 中,手的参与导致了75%的整体残疾.
- 在SSc手损伤中存在显著的个体变异性.
- 之前的研究没有直接比较SSc患者的主导手和逆侧手之间的功能差异.
研究的目的:
- 评估和比较系统性硬化症患者的主导和非主导手之间的关节限制和皮肤干扰严重程度.
- 在SSc手表现中识别潜在的不对称性.
主要方法:
- 对符合ACR/EULAR标准的SSc患者进行前性,描述性,比较性研究.
- 评估包括联合范围的运动 (主动/被动),第一个 commissure 开放, Kapandji 和 Rodnan 手的分数,数字压力和数字.
- 对于每个患者,对主导和逆侧手进行了评估.
主要成果:
- 分析了30名SSc患者的情况.
- 占主导地位的手表现出明显更大的自发曲限制 (p<0.0001).
- 主导手的卡潘吉分数较低 (p<0.001) 和罗丹手分数较高 (p<0.001),表明更严重的皮肤硬化和功能障碍.
结论:
- 与非主导手相比,SSc患者的主导手表现出明显增加的皮肤硬化和曲恶化.
- 在占主导地位的手中观察到减少伸展的趋势,以及较低的功能评分.
- 两手之间没有发现显著的血管病理差异,但建议进行更大规模的研究来证实研究结果并指导治疗.
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