针对肥胖患者的最新抗菌剂剂量建议
Ana Castro-Balado1,2, Iria Varela-Rey1,2, Beatriz Mejuto1
1Pharmacy Department, University Clinical Hospital of Santiago de Compostela (SERGAS), Santiago de Compostela, Spain.
Antimicrobial agents and chemotherapy
|March 25, 2024
概括
肥胖会改变药物行为,影响抗微生物药物的有效性. 本综述对肥胖患者的抗微生物剂量策略进行了批判性评估,以防止治疗失败或毒性.
科学领域:
- 药理学 药理学是指药理学的学科.
- 传染性疾病 传染性疾病
- 临床药房 临床药房
背景情况:
- 全球肥胖率的上升在临床实践中带来了独特的挑战.
- 与肥胖相关的生理变化显著影响药物药理动力学 (PK) 和药理动力学 (PD).
- 标准抗微生物剂量可能在肥胖个体中不足于最佳水平,冒着治疗失败或不良事件的风险.
研究的目的:
- 对肥胖成年患者的抗菌剂剂量策略进行全面审查和批判性评估.
- 整合各种类型的抗微生物药物在肥胖中的可用的药理动力学和药理动力学数据.
- 为了应对这个群体寻找明确和一致的剂量指南的挑战.
主要方法:
- 对药理动力学 (PK) 和药理动力学 (PD) 数据的系统文献综述.
- 对已发表的关于肥胖成年人抗菌剂剂量的研究进行批判性评估.
- 包括关于抗生素,抗真菌药物,抗病毒药物和抗结核药物的数据.
主要成果:
- 肥胖会显著改变抗微生物药物的吸收,分布,新陈代谢和分泌.
- 证据支持在肥胖患者中对许多抗微生物药物的修改剂量方案.
- 经常建议使用延长输液策略和基于体重的剂量.
结论:
- 优化抗微生物剂量对于肥胖患者的有效治疗至关重要.
- 需要进一步的研究来完善所有类别的抗微生物药物的剂量指南.
- 临床医生应仔细考虑患者的体重和PK/PD变化,在给肥胖个体开抗菌药时.
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