对肠道和皮肤微生物群的双重干预减弱了面部皮肤衰老
Liujing Zhang1, Shun Yu2, Yin Guan3
1State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, China. Zhaow@jiangnan.edu.cn.
Food & function
|March 25, 2024
概括
通过调节肠 - 皮肤轴,双氧化糖 (XOS) 干预改善了面部皮肤的老化. 这种方法通过调节肠道和皮肤微生物群来增强皮肤复发和减少面部毛孔.
科学领域:
- 微生物学 微生物学
- 皮肤病学 皮肤病学
- 衰老研究研究 衰老研究
背景情况:
- 肠道和皮肤微生物群作为关键的微生物障碍物,维持平衡并抵抗病原体.
- 这些微生物群中的失生物与衰老过程有关.
- 针对面部衰老的肠-皮肤轴的干预措施是有限的.
研究的目的:
- 调查口服 (O),局部 (T) 和口服和局部 (OT) 结合的西-寡糖 (XOS) 对面部皮肤衰老的影响.
- 评估XOS干预对肠道和皮肤微生物群组成和功能的影响.
- 探索微生物群调节和面部皮肤改善之间的关系.
主要方法:
- 这是一项为期八周的双盲,安慰剂对照试验,涉及女性.
- 通过口服,局部和联合途径给药XOS.
- 分析面部皮肤状况 (例如,毛孔,复发) 和肠道/皮肤微生物群组成.
- 用于微生物功能预测的生物信息分析.
主要成果:
- 结合口服和局部 (OT) XOS干预表明,参与者中皮肤复发的比例更高,面孔显著减少.
- 与单独的O或T相比,OT干预导致皮肤Cutibacterium的减少更大.
- 肠道Bifidobacterium仅在OT组中进行了丰富.
- 功能分析表明,与新型脂质合成相关的基因减少,可能与减少的脂性Cutibacterium和毛孔大小有关.
结论:
- 结合口服和局部XOS干预是改善面部皮肤衰老的最有效策略.
- 这种双重方法优化了肠道和皮肤微生物群,从而改善了皮肤健康.
- 通过XOS调节肠-皮肤轴对抗衰老的护肤有希望.
相关概念视频
01:23Skin Diseases and Disorders
3.8K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
3.8K
01:18Surface Membrane Barriers
1.1K
The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
1.1K
01:26Defense Mechanism Against Infection
6.5K
Natural flora, body system defenses, and inflammation are natural barriers of the body against infectious agents regardless of previous exposure. Normal floras of the human body refer to the microbial population that colonizes the skin and mucous membranes.
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
6.5K