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Updated: Jun 29, 2025

Using Next Generation Sequencing to Identify Mutations Associated with Repair of a CAS9-induced Double Strand Break Near the CD4 Promoter
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通过对DNA损伤反应标记物的分析,识别不同类型的基因组不稳定性抑制基因

Bin-Zhong Li1, Richard D Kolodner1,2,3,4, Christopher D Putnam1,5

  • 1Ludwig Institute for Cancer Research, San Diego Branch, La Jolla, CA 92093-0669, USA.

G3 (Bethesda, Md.)
|March 25, 2024
PubMed
概括

研究人员确定了在酵母中抑制DNA损伤 (DDS) 和基因组不稳定 (DGIS) 的不同基因组. 这些发现揭示了DNA损伤标记不能可靠地表明基因组不稳定性,突出了机理上不同的基因功能.

关键词:
DNA 损伤信号传递信号.修复DNA的修复DNA的修复基因组的不稳定性

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